Diffuse Lewy body disease - Neuropathological and biochemical studies of six patients

D. W. Dickson, P. Davies, R. Mayeux, H. Crystal, D. S. Horoupian, A. Thompson, J. E. Goldman

Research output: Contribution to journalArticle

147 Scopus citations

Abstract

Post-mortem pathological and biochemical studies are reported on six patients with progressive dementia. The characteristic pathological finding was neurofilament-containing cytoplasmic inclusions in cortical and subcortical neurons. The clinical and pathological findings were consistent with so-called diffuse Lewy body disease. The patients had variable changes of the Alzheimer type, with five of six patients displaying "plaques only" Alzheimer's changes. Biochemical studies showed profound decreases in neocortical choline acetyltransferase (ChAT) activities that correlated with marked neuronal loss in the basal nucleus of Meynert. ChAT activities were normal in the hippocampus in three patients who also had no significant Alzheimer type hippocampal changes. All patients had decreased cortical somatostatin-like immunoreactivity. Our observations suggest that dementia in diffuse Lewy body disease bears biochemical similarities to Alzheimer's disease, in that biochemical markers for both intrinsic cortical neurons and ascending cholinergic neurons are affected.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalActa neuropathologica
Volume75
Issue number1
DOIs
StatePublished - Jan 1987

Keywords

  • Choline acetyltransferase
  • Lewy body
  • Parkinson's disease
  • Somatostatin
  • Thioflavine S

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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    Dickson, D. W., Davies, P., Mayeux, R., Crystal, H., Horoupian, D. S., Thompson, A., & Goldman, J. E. (1987). Diffuse Lewy body disease - Neuropathological and biochemical studies of six patients. Acta neuropathologica, 75(1), 8-15. https://doi.org/10.1007/BF00686786