Diffuse dermal angiomatosis of the breast

Hongyu Yang, Iftikhar Ahmed, Verghese Mathew, Arnold L. Schroeter

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Diffuse dermal angiomatosis is rare and usually considered a variant of reactive angioendotheliomatosis. It generally involves the extremities of patients with severe vascular disease and other comorbidities. Two patients with breast involvement have been described; however, neither had a relevant medical history or a vaso-occlusive disorder, but both had large pendulous breasts, and 1 was positive for IgM anticardiolipin and antinuclear antibodies. Observations: A 53-year-old woman had a reticulated, erythematous plaque with superficial ulceration and underlying tender nodules on her left breast. She had a history of cardiovascular disease and was a heavy smoker. Biopsy of the lesion showed diffuse proliferation of additional endothelial cells and small bland vessels within the papillary and upper reticular dermis. Angiography showed almost complete occlusion of the subclavian artery proximally. Diffuse dermal angiomatosis was diagnosed. With isotretinoin therapy, the lesions improved.Onemonth later, after percutaneous subclavian arterial revascularization, the lesion resolved completely. A literature review suggested that a history of heavy smoking, in addition to a history of vascular disease, may be important in the pathogenesis of diffuse dermal angiomatosis. Conclusions: Clinical acumen is crucial to diagnose diffuse angiomatosis of the breast. Appropriate treatment to alleviate hypoxia may improve the patient's condition.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalArchives of Dermatology
Volume142
Issue number3
DOIs
StatePublished - Mar 2006

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Angiomatosis
Breast
Skin
Vascular Diseases
Anticardiolipin Antibodies
Isotretinoin
Subclavian Artery
Antinuclear Antibodies
Dermis
Immunoglobulin M
Comorbidity
Angiography
Cardiovascular Diseases
Extremities
Endothelial Cells
Smoking
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Yang, H., Ahmed, I., Mathew, V., & Schroeter, A. L. (2006). Diffuse dermal angiomatosis of the breast. Archives of Dermatology, 142(3), 343-347. https://doi.org/10.1001/archderm.142.3.343

Diffuse dermal angiomatosis of the breast. / Yang, Hongyu; Ahmed, Iftikhar; Mathew, Verghese; Schroeter, Arnold L.

In: Archives of Dermatology, Vol. 142, No. 3, 03.2006, p. 343-347.

Research output: Contribution to journalArticle

Yang, H, Ahmed, I, Mathew, V & Schroeter, AL 2006, 'Diffuse dermal angiomatosis of the breast', Archives of Dermatology, vol. 142, no. 3, pp. 343-347. https://doi.org/10.1001/archderm.142.3.343
Yang, Hongyu ; Ahmed, Iftikhar ; Mathew, Verghese ; Schroeter, Arnold L. / Diffuse dermal angiomatosis of the breast. In: Archives of Dermatology. 2006 ; Vol. 142, No. 3. pp. 343-347.
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