Differentiation of uric acid versus non-uric acid kidney stones in the presence of iodine using dual-energy CT

J. Wang, M. Qu, S. Leng, C. H. McCollough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

In this study, the feasibility of differentiating uric acid from non-uric acid kidney stones in the presence of iodinated contrast material was evaluated using dual-energy CT (DECT). Iodine subtraction was accomplished with a commercial three material decomposition algorithm to create a virtual non-contrast (VNC) image set. VNC images were then used to segment stone regions from tissue background. The DE ratio of each stone was calculated using the CT images acquired at two different energies with DECT using the stone map generated from the VNC images. The performance of DE ratio-based stone differentiation was evaluated at five different iodine concentrations (21, 42, 63, 84 and 105 mg/ml). The DE ratio of stones in iodine solution was found larger than those obtained in non-iodine cases. This is mainly caused by the partial volume effect around the boundary between the stone and iodine solution. The overestimation of the DE ratio leads to substantial overlap between different stone types. To address the partial volume effect, an expectation-maximization (EM) approach was implemented to estimate the contribution of iodine and stone within each image pixel in their mixture area. The DE ratio of each stone was corrected to maximally remove the influence of iodine solutions. The separation of uric-acid and non-uric-acid stone was improved in the presence of iodine solution.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2010
Subtitle of host publicationPhysics of Medical Imaging
EditionPART 2
DOIs
StatePublished - Dec 1 2010
EventMedical Imaging 2010: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 15 2010Feb 18 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 2
Volume7622
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2010: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/15/102/18/10

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Wang, J., Qu, M., Leng, S., & McCollough, C. H. (2010). Differentiation of uric acid versus non-uric acid kidney stones in the presence of iodine using dual-energy CT. In Medical Imaging 2010: Physics of Medical Imaging (PART 2 ed.). [76223O] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7622, No. PART 2). https://doi.org/10.1117/12.845046