Differential spectral quantitative electroencephalography patterns between control and Parkinson's disease cohorts

John Nathaniel Caviness, Rene Utianski, J. G. Hentz, T. G. Beach, B. N. Dugger, H. A. Shill, Erika M Driver-Dunckley, M. N. Sabbagh, Shyamal Mehta, Charles Howard Adler

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background and purpose: It is believed that progressive Lewy-type synucleinopathy (LTS) is primarily responsible for the worsening of motor and non-motor Parkinson's disease (PD) signs and symptoms. Characterization of quantitative electroencephalography (QEEG) abnormalities across the spectrum of LTS to PD dementia (PD-D) may provide insight into the pathophysiology of PD cortical dysfunction. Here our enlarged EEG database was leveraged to characterize spectral QEEG abnormalities in asymptomatic autopsy-defined groups of control participants and incidental Lewy body disease (ILBD) and three clinically defined groups of participants with PD (cognitively normal PD, mild cognitive impairment PD, and PD-D). Methods: The PD cohort was studied as part of the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). AZSAND utilizes its Brain and Body Donation Program to perform prospective, standardized, regular longitudinal pre-mortem assessments until death. Resting EEG from subjects was analyzed for spectral domain QEEG measures of background rhythm frequency and global relative power in delta, theta, alpha and beta bands. Results: The various spectral QEEG measures showed differential changes specific to the groups compared. Important findings were background rhythm frequency showing the most pairwise differences across the groups, and this also was the only significant difference between control and ILBD. An increase in delta bandpower was characteristic of worsening cognitive deficits. Conclusions: Different patterns of change amongst QEEG measures across LTS and PD cognitive states suggest that they correlate with heterogeneous pathophysiologies of cortical dysfunction within the PD clinical spectrum. In addition, the biomarker application of a specific spectral QEEG measure needs to be selectively suited to its study purpose. European Journal of Neurology

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalEuropean Journal of Neurology
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Parkinson Disease
Electroencephalography
Lewy Body Disease
Neurodegenerative Diseases
Neurology
Signs and Symptoms
Dementia
Autopsy
Biomarkers
Databases
Control Groups
Brain

Keywords

  • Biomarker
  • Dementia
  • EEG
  • Parkinson's disease
  • Pathology
  • Synucleinopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Differential spectral quantitative electroencephalography patterns between control and Parkinson's disease cohorts. / Caviness, John Nathaniel; Utianski, Rene; Hentz, J. G.; Beach, T. G.; Dugger, B. N.; Shill, H. A.; Driver-Dunckley, Erika M; Sabbagh, M. N.; Mehta, Shyamal; Adler, Charles Howard.

In: European Journal of Neurology, Vol. 23, No. 2, 01.02.2016, p. 387-392.

Research output: Contribution to journalArticle

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abstract = "Background and purpose: It is believed that progressive Lewy-type synucleinopathy (LTS) is primarily responsible for the worsening of motor and non-motor Parkinson's disease (PD) signs and symptoms. Characterization of quantitative electroencephalography (QEEG) abnormalities across the spectrum of LTS to PD dementia (PD-D) may provide insight into the pathophysiology of PD cortical dysfunction. Here our enlarged EEG database was leveraged to characterize spectral QEEG abnormalities in asymptomatic autopsy-defined groups of control participants and incidental Lewy body disease (ILBD) and three clinically defined groups of participants with PD (cognitively normal PD, mild cognitive impairment PD, and PD-D). Methods: The PD cohort was studied as part of the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). AZSAND utilizes its Brain and Body Donation Program to perform prospective, standardized, regular longitudinal pre-mortem assessments until death. Resting EEG from subjects was analyzed for spectral domain QEEG measures of background rhythm frequency and global relative power in delta, theta, alpha and beta bands. Results: The various spectral QEEG measures showed differential changes specific to the groups compared. Important findings were background rhythm frequency showing the most pairwise differences across the groups, and this also was the only significant difference between control and ILBD. An increase in delta bandpower was characteristic of worsening cognitive deficits. Conclusions: Different patterns of change amongst QEEG measures across LTS and PD cognitive states suggest that they correlate with heterogeneous pathophysiologies of cortical dysfunction within the PD clinical spectrum. In addition, the biomarker application of a specific spectral QEEG measure needs to be selectively suited to its study purpose. European Journal of Neurology",
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AU - Shill, H. A.

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