Differential role of PTEN phosphatase in chemotactic growth cone guidance

Steven J. Henle, Lucas P. Carlstrom, Thomas R. Cheever, John R. Henley

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: The phosphatase PTEN is implicated in suppressing neuroregeneration following injury. Results: Chemorepulsion of axons by distinct cues, but not chemoattraction, correlates with PTEN activity, depression of phosphatidylinositol signaling, and remodeling of integrin adhesions. Conclusion: PTEN mediates chemorepulsion selectively. Significance: Suppressing PTEN activity may block repulsion by negative cues after injury while permitting attractive guidance of regenerating axons.

Original languageEnglish (US)
Pages (from-to)20837-20842
Number of pages6
JournalJournal of Biological Chemistry
Volume288
Issue number29
DOIs
StatePublished - Jul 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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