Differential health benefits of weight loss in upper-body and lower-body obese women

J. A. Kanaley, M. L. Andresen-Reid, L. Oenning, B. A. Kottke, M. D. Jensen

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Upper-body obesity (UB Ob) is more strongly associated with adverse health consequences: however, few obesity-treatment studies have examined outcome according to body-fat distribution. To examine whether diet and formal- or informal-exercise instruction causes differential changes in health and lipid profiles, ten LB Ob and nine UB Ob premenopausal women received dietary intervention (2.1 MJ-deficit/d for 16 wk) and were randomly assigned to either formal- or informal-exercise instruction. Weight loss was similar between groups (≃8 kg), and no change occurred in lean body mass or basal metabolic rate. Baseline cholesterol and triglycerides were greater (P < 0.01) in UB Ob than LB Ob women and decreased more (P < 0.01) in response to treatment in UB Ob women. Formal exercise instruction increased high-density- lipoprotein cholesterol (P < 0.05) especially in UB Ob women. Future studies on treatment of obesity should include consideration of regional fat distribution.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Issue number1
StatePublished - 1993


  • Body composition
  • caloric restriction
  • exercise
  • plasma lipids and lipoproteins

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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