Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder

Animesh Pardanani, Teresa K. Kimlinger, Terra L. Reeder, Chin Yang Li, Ayalew Tefferi

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so-called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0.04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients.

Original languageEnglish (US)
Pages (from-to)691-694
Number of pages4
JournalBritish journal of haematology
Volume120
Issue number4
DOIs
StatePublished - Feb 1 2003

Keywords

  • CD2 expression
  • Mast cells
  • Systemic mast cell disease

ASJC Scopus subject areas

  • Hematology

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