Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder

Animesh Pardanani; Teresa K. Kimlinger; Terra L. Reeder; Chin Yang Li; Ayalew Tefferi

doi:10.1046/j.1365-2141.2003.04125.x

Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder

Animesh Pardanani, Teresa K. Kimlinger, Terra L. Reeder, Chin Yang Li, Ayalew Tefferi

Hematology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so-called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0.04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients.

Original language	English (US)
Pages (from-to)	691-694
Number of pages	4
Journal	British journal of haematology
Volume	120
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.2003.04125.x
State	Published - Feb 2003

Keywords

CD2 expression
Mast cells
Systemic mast cell disease

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2003.04125.x

Cite this

Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder. / Pardanani, Animesh; Kimlinger, Teresa K.; Reeder, Terra L. et al.
In: British journal of haematology, Vol. 120, No. 4, 02.2003, p. 691-694.

Research output: Contribution to journal › Article › peer-review

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abstract = "Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so-called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0.04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients.",

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AU - Tefferi, Ayalew

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AB - Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so-called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0.04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients.

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Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder

Abstract

Keywords

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