Differential effects of response-contingent and response-independent nicotine in rats

Eric C. Donny, Anthony R. Caggiula, Christine Rose, Kimberly S. Jacobs, Michelle M Mielke, Alan F. Sved

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Passive administration of nicotine activates the hypothalamic-pituitary- adrenocortical axis and sympathetic nervous system. However, little is known about the effects of self-administered nicotine. Drug-naive rats were trained to respond for food reinforcement and then tested in one, 1-h session in which they received response-contingent i.v. nicotine or response-independent i.v. nicotine or saline. Blood draws were taken immediately prior to the session, 15 min after the first infusion and immediately after the session. Both response-contingent and response-independent nicotine (RI/N) increased corticosterone within 15 min, however, corticosterone levels returned to baseline in animals receiving response-contingent nicotine (RC/N) by the end of the session while remaining elevated in those receiving RI/N. Furthermore, only RI/N increased plasma epinephrine and norepinephrine levels; RC/N produced no effect. These differences indicate that nicotine's acute effects are powerfully modified by the presence of a contingency relationship between drug administration and the animal's behavior and that this relationship develops very rapidly. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)231-240
Number of pages10
JournalEuropean Journal of Pharmacology
Volume402
Issue number3
DOIs
StatePublished - Aug 25 2000
Externally publishedYes

Fingerprint

Nicotine
Corticosterone
Animal Behavior
Sympathetic Nervous System
Pharmaceutical Preparations
Epinephrine
Norepinephrine
Food

Keywords

  • Catecholamine
  • Corticosterone
  • Epinephrine
  • Nicotine
  • Norepinephrine
  • Self- administration
  • Yoking

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Differential effects of response-contingent and response-independent nicotine in rats. / Donny, Eric C.; Caggiula, Anthony R.; Rose, Christine; Jacobs, Kimberly S.; Mielke, Michelle M; Sved, Alan F.

In: European Journal of Pharmacology, Vol. 402, No. 3, 25.08.2000, p. 231-240.

Research output: Contribution to journalArticle

Donny, Eric C. ; Caggiula, Anthony R. ; Rose, Christine ; Jacobs, Kimberly S. ; Mielke, Michelle M ; Sved, Alan F. / Differential effects of response-contingent and response-independent nicotine in rats. In: European Journal of Pharmacology. 2000 ; Vol. 402, No. 3. pp. 231-240.
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