Differential effects of digitalis on chemoreflex responses in humans

Hans P. Schobel, David W. Ferguson, Mary P. Clary, Virend Somers

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To investigate the effects of digitalis on chemoreflexes in humans, we measured muscle sympathetic nerve activity (microneurography), minute ventilation, oxygen saturation, end-tidal carbon dioxide, mean arterial pressure, heart rate, and central venous pressure during stimulation of peripheral chemoreceptors with hypoxia, during stimulation of central chemoreceptors with hypercapnia, and during a cold pressor test before and after digitalis and placebo in 10 healthy volunteers on two different days (randomized, double-blind, cross-over design). Digitalis did not affect baseline measurements significantly. Despite similar changes in oxygen saturation and end-tidal carbon dioxide during hypoxia and hypercapnia with both placebo and digitalis, digitalis significantly potentiated overall ventilatory responses to hypoxia (+67±12% before versus +98±3% after digitalis; mean±SEM; P<.01) but did not affect the response to hypercapnia. Sympathetic nerve activity increased by 25±9% during hypoxia before digitalis and 30±10% during hypoxia after digitalis (P=NS) and increased by 38±18% during hypercapnia before digitalis and 26±11% during hypercapnia after digitalis (P=NS). Digitalis did not significantly change responses to the cold pressor test. Placebo had no effect on ventilatory and sympathetic nerve activity responses. We conclude that digitalis selectively augments ventilatory responses to peripheral chemoreceptor stimulation by hypoxia.

Original languageEnglish (US)
Pages (from-to)302-307
Number of pages6
JournalHypertension
Volume23
Issue number3
StatePublished - Mar 1994
Externally publishedYes

Fingerprint

Digitalis
Hypercapnia
Placebos
Carbon Dioxide
Oxygen
Central Venous Pressure
Cross-Over Studies
Ventilation
Hypoxia
Healthy Volunteers
Arterial Pressure
Heart Rate

Keywords

  • apnea
  • chemoreceptors
  • digitalis
  • sympathetic nervous system
  • ventilation

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Schobel, H. P., Ferguson, D. W., Clary, M. P., & Somers, V. (1994). Differential effects of digitalis on chemoreflex responses in humans. Hypertension, 23(3), 302-307.

Differential effects of digitalis on chemoreflex responses in humans. / Schobel, Hans P.; Ferguson, David W.; Clary, Mary P.; Somers, Virend.

In: Hypertension, Vol. 23, No. 3, 03.1994, p. 302-307.

Research output: Contribution to journalArticle

Schobel, HP, Ferguson, DW, Clary, MP & Somers, V 1994, 'Differential effects of digitalis on chemoreflex responses in humans', Hypertension, vol. 23, no. 3, pp. 302-307.
Schobel HP, Ferguson DW, Clary MP, Somers V. Differential effects of digitalis on chemoreflex responses in humans. Hypertension. 1994 Mar;23(3):302-307.
Schobel, Hans P. ; Ferguson, David W. ; Clary, Mary P. ; Somers, Virend. / Differential effects of digitalis on chemoreflex responses in humans. In: Hypertension. 1994 ; Vol. 23, No. 3. pp. 302-307.
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