Differential durability of immune responses to measles and mumps following MMR vaccination

Richard B. Kennedy, Inna G. Ovsyannikova, Antonia Thomas, Beth R. Larrabee, Steven Rubin, Gregory A. Poland

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The development and wide-spread use of mumps vaccine resulted in a dramatic and sustained decrease in the incidence of mumps disease; however, since 2000, an increase in the size and number of mumps outbreaks in the United States and other countries has sparked renewed interest in the durability of mumps-specific immunity elicited by mumps vaccination. The most likely explanation for mumps cases in previously immunized persons may be secondary vaccine failure, or waning immunity. In the current study, we examined changes in markers of measles and mumps immunity at two timepoints, approximately 7 and 17 years after two-dose MMR-II® vaccination, in a cohort of 98 healthy adults. Our results indicate that mumps IgG titers exhibited a large and significant decline during this time period, while mumps neutralizing Ab titers were relatively stable. There was a similar discrepancy with measles-specific immune responses. For both pathogens, neutralizing antibody titers were fairly low and, given the length of time since vaccination, may have already declined. These data suggest that specific immune outcomes may wane at different rates and highlight our currently incomplete understanding of protective immune responses to mumps and measles.

Original languageEnglish (US)
Pages (from-to)1775-1784
Number of pages10
Issue number13
StatePublished - Mar 22 2019


  • Antibodies
  • Cell-mediated immunity
  • Humoral immunity
  • MMR-II vaccine
  • Measles
  • Measles vaccine
  • Measles virus
  • Mumps
  • Mumps vaccine
  • Mumps virus
  • T cell ELISPOT

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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