Abstract
The development and wide-spread use of mumps vaccine resulted in a dramatic and sustained decrease in the incidence of mumps disease; however, since 2000, an increase in the size and number of mumps outbreaks in the United States and other countries has sparked renewed interest in the durability of mumps-specific immunity elicited by mumps vaccination. The most likely explanation for mumps cases in previously immunized persons may be secondary vaccine failure, or waning immunity. In the current study, we examined changes in markers of measles and mumps immunity at two timepoints, approximately 7 and 17 years after two-dose MMR-II® vaccination, in a cohort of 98 healthy adults. Our results indicate that mumps IgG titers exhibited a large and significant decline during this time period, while mumps neutralizing Ab titers were relatively stable. There was a similar discrepancy with measles-specific immune responses. For both pathogens, neutralizing antibody titers were fairly low and, given the length of time since vaccination, may have already declined. These data suggest that specific immune outcomes may wane at different rates and highlight our currently incomplete understanding of protective immune responses to mumps and measles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1775-1784 |
| Number of pages | 10 |
| Journal | Vaccine |
| Volume | 37 |
| Issue number | 13 |
| DOIs | |
| State | Published - Mar 22 2019 |
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Keywords
- Antibodies
- Cell-mediated immunity
- Humoral immunity
- Measles
- Measles vaccine
- Measles virus
- MMR-II vaccine
- Mumps
- Mumps vaccine
- Mumps virus
- T cell ELISPOT
ASJC Scopus subject areas
- Molecular Medicine
- Immunology and Microbiology(all)
- veterinary(all)
- Public Health, Environmental and Occupational Health
- Infectious Diseases
Cite this
Differential durability of immune responses to measles and mumps following MMR vaccination. / Kennedy, Richard B; Ovsyannikova, Inna G.; Thomas, Antonia; Larrabee, Beth R.; Rubin, Steven; Poland, Gregory A.
In: Vaccine, Vol. 37, No. 13, 22.03.2019, p. 1775-1784.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential durability of immune responses to measles and mumps following MMR vaccination
AU - Kennedy, Richard B
AU - Ovsyannikova, Inna G.
AU - Thomas, Antonia
AU - Larrabee, Beth R.
AU - Rubin, Steven
AU - Poland, Gregory A.
PY - 2019/3/22
Y1 - 2019/3/22
N2 - The development and wide-spread use of mumps vaccine resulted in a dramatic and sustained decrease in the incidence of mumps disease; however, since 2000, an increase in the size and number of mumps outbreaks in the United States and other countries has sparked renewed interest in the durability of mumps-specific immunity elicited by mumps vaccination. The most likely explanation for mumps cases in previously immunized persons may be secondary vaccine failure, or waning immunity. In the current study, we examined changes in markers of measles and mumps immunity at two timepoints, approximately 7 and 17 years after two-dose MMR-II® vaccination, in a cohort of 98 healthy adults. Our results indicate that mumps IgG titers exhibited a large and significant decline during this time period, while mumps neutralizing Ab titers were relatively stable. There was a similar discrepancy with measles-specific immune responses. For both pathogens, neutralizing antibody titers were fairly low and, given the length of time since vaccination, may have already declined. These data suggest that specific immune outcomes may wane at different rates and highlight our currently incomplete understanding of protective immune responses to mumps and measles.
AB - The development and wide-spread use of mumps vaccine resulted in a dramatic and sustained decrease in the incidence of mumps disease; however, since 2000, an increase in the size and number of mumps outbreaks in the United States and other countries has sparked renewed interest in the durability of mumps-specific immunity elicited by mumps vaccination. The most likely explanation for mumps cases in previously immunized persons may be secondary vaccine failure, or waning immunity. In the current study, we examined changes in markers of measles and mumps immunity at two timepoints, approximately 7 and 17 years after two-dose MMR-II® vaccination, in a cohort of 98 healthy adults. Our results indicate that mumps IgG titers exhibited a large and significant decline during this time period, while mumps neutralizing Ab titers were relatively stable. There was a similar discrepancy with measles-specific immune responses. For both pathogens, neutralizing antibody titers were fairly low and, given the length of time since vaccination, may have already declined. These data suggest that specific immune outcomes may wane at different rates and highlight our currently incomplete understanding of protective immune responses to mumps and measles.
KW - Antibodies
KW - Cell-mediated immunity
KW - Humoral immunity
KW - Measles
KW - Measles vaccine
KW - Measles virus
KW - MMR-II vaccine
KW - Mumps
KW - Mumps vaccine
KW - Mumps virus
KW - T cell ELISPOT
UR - http://www.scopus.com/inward/record.url?scp=85061647595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061647595&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2019.02.030
DO - 10.1016/j.vaccine.2019.02.030
M3 - Article
C2 - 30797639
AN - SCOPUS:85061647595
VL - 37
SP - 1775
EP - 1784
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 13
ER -