Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation

Philippe Van De Borne, Jolanta Neubauer, Mohsen Rahnama, Jean Luc Jansens, Nicola Montano, Alberto Porta, Virend Somers, Jean Paul Degaute

Research output: Contribution to journalArticle

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Abstract

Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P<0.05). Normalized LF variability was also higher in the long-term HTRs (40±14 normalized unites) versus the short-term HTRs (6±3 normalized united, P<0.05) but did not differ from the LF variability of the hypertensive patients. Long-term HTRs were taking less cyclosporine (P<0.01) but had higher MSNA than the short-term HTRs (62±7 versus 31±7 burst/min, respectively, P<0.05). Coherence between LF oscillations in MSNA and RR was similar in the long-term HTRs (0.59±0.11) and the hypertensive patients (0.60±0.07) and was 3-fold greater than in the short-term HTRs (0.20±0.06, P<0.05). Conclusions - Cardiac reinnervation after long-term heart transplantation is characterized by a restoration of the coherence between LF oscillations in RR and MSNA. Higher MSNA in long-term than in short-term HTRs suggests that time elapsed after cardiac transplantation may be a major determinant of sympathetic excitation in heart transplant recipients.

Original languageEnglish (US)
Pages (from-to)1809-1813
Number of pages5
JournalCirculation
Volume104
Issue number15
StatePublished - Oct 9 2001

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Heart Transplantation
Muscles
Transplant Recipients
Cyclosporine

Keywords

  • Circulation
  • Nervous system, sympathetic
  • Transplantation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Van De Borne, P., Neubauer, J., Rahnama, M., Jansens, J. L., Montano, N., Porta, A., ... Degaute, J. P. (2001). Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation. Circulation, 104(15), 1809-1813.

Differential characteristics of neural circulatory control : Early versus late after cardiac transplantation. / Van De Borne, Philippe; Neubauer, Jolanta; Rahnama, Mohsen; Jansens, Jean Luc; Montano, Nicola; Porta, Alberto; Somers, Virend; Degaute, Jean Paul.

In: Circulation, Vol. 104, No. 15, 09.10.2001, p. 1809-1813.

Research output: Contribution to journalArticle

Van De Borne, P, Neubauer, J, Rahnama, M, Jansens, JL, Montano, N, Porta, A, Somers, V & Degaute, JP 2001, 'Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation', Circulation, vol. 104, no. 15, pp. 1809-1813.
Van De Borne P, Neubauer J, Rahnama M, Jansens JL, Montano N, Porta A et al. Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation. Circulation. 2001 Oct 9;104(15):1809-1813.
Van De Borne, Philippe ; Neubauer, Jolanta ; Rahnama, Mohsen ; Jansens, Jean Luc ; Montano, Nicola ; Porta, Alberto ; Somers, Virend ; Degaute, Jean Paul. / Differential characteristics of neural circulatory control : Early versus late after cardiac transplantation. In: Circulation. 2001 ; Vol. 104, No. 15. pp. 1809-1813.
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title = "Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation",
abstract = "Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P<0.05). Normalized LF variability was also higher in the long-term HTRs (40±14 normalized unites) versus the short-term HTRs (6±3 normalized united, P<0.05) but did not differ from the LF variability of the hypertensive patients. Long-term HTRs were taking less cyclosporine (P<0.01) but had higher MSNA than the short-term HTRs (62±7 versus 31±7 burst/min, respectively, P<0.05). Coherence between LF oscillations in MSNA and RR was similar in the long-term HTRs (0.59±0.11) and the hypertensive patients (0.60±0.07) and was 3-fold greater than in the short-term HTRs (0.20±0.06, P<0.05). Conclusions - Cardiac reinnervation after long-term heart transplantation is characterized by a restoration of the coherence between LF oscillations in RR and MSNA. Higher MSNA in long-term than in short-term HTRs suggests that time elapsed after cardiac transplantation may be a major determinant of sympathetic excitation in heart transplant recipients.",
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T2 - Early versus late after cardiac transplantation

AU - Van De Borne, Philippe

AU - Neubauer, Jolanta

AU - Rahnama, Mohsen

AU - Jansens, Jean Luc

AU - Montano, Nicola

AU - Porta, Alberto

AU - Somers, Virend

AU - Degaute, Jean Paul

PY - 2001/10/9

Y1 - 2001/10/9

N2 - Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P<0.05). Normalized LF variability was also higher in the long-term HTRs (40±14 normalized unites) versus the short-term HTRs (6±3 normalized united, P<0.05) but did not differ from the LF variability of the hypertensive patients. Long-term HTRs were taking less cyclosporine (P<0.01) but had higher MSNA than the short-term HTRs (62±7 versus 31±7 burst/min, respectively, P<0.05). Coherence between LF oscillations in MSNA and RR was similar in the long-term HTRs (0.59±0.11) and the hypertensive patients (0.60±0.07) and was 3-fold greater than in the short-term HTRs (0.20±0.06, P<0.05). Conclusions - Cardiac reinnervation after long-term heart transplantation is characterized by a restoration of the coherence between LF oscillations in RR and MSNA. Higher MSNA in long-term than in short-term HTRs suggests that time elapsed after cardiac transplantation may be a major determinant of sympathetic excitation in heart transplant recipients.

AB - Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P<0.05). Normalized LF variability was also higher in the long-term HTRs (40±14 normalized unites) versus the short-term HTRs (6±3 normalized united, P<0.05) but did not differ from the LF variability of the hypertensive patients. Long-term HTRs were taking less cyclosporine (P<0.01) but had higher MSNA than the short-term HTRs (62±7 versus 31±7 burst/min, respectively, P<0.05). Coherence between LF oscillations in MSNA and RR was similar in the long-term HTRs (0.59±0.11) and the hypertensive patients (0.60±0.07) and was 3-fold greater than in the short-term HTRs (0.20±0.06, P<0.05). Conclusions - Cardiac reinnervation after long-term heart transplantation is characterized by a restoration of the coherence between LF oscillations in RR and MSNA. Higher MSNA in long-term than in short-term HTRs suggests that time elapsed after cardiac transplantation may be a major determinant of sympathetic excitation in heart transplant recipients.

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KW - Nervous system, sympathetic

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