TY - JOUR
T1 - Differential cellular response within the rabbit tendon unit following tendon injury
AU - Kakar, S.
AU - Khan, U.
AU - McGrouther, D. A.
PY - 1998
Y1 - 1998
N2 - The cellular changes in the epitenon, endotenon and synovial sheath were investigated in a rabbit model after a partial transverse laceration was made on the plantar aspect of the flexor digitorum profundus proximal to the synovial sheath (which was not injured). Fibroblasts, macrophages and mast cells within the epitenon, endotenon and synovial sheath were counted on electron micrographs. The epitenon and uninjured synovial sheath became engorged with fibroblasts and macrophages following injury. The number of synovial fibroblasts showed the greatest increase during the first week after injury, In comparison, the endotenon exhibited a delay in cellular response with initial apoptosis, as judged by positive P53 staining. However, hypercellular activity was seen within the endotenon at 12 weeks postoperatively.
AB - The cellular changes in the epitenon, endotenon and synovial sheath were investigated in a rabbit model after a partial transverse laceration was made on the plantar aspect of the flexor digitorum profundus proximal to the synovial sheath (which was not injured). Fibroblasts, macrophages and mast cells within the epitenon, endotenon and synovial sheath were counted on electron micrographs. The epitenon and uninjured synovial sheath became engorged with fibroblasts and macrophages following injury. The number of synovial fibroblasts showed the greatest increase during the first week after injury, In comparison, the endotenon exhibited a delay in cellular response with initial apoptosis, as judged by positive P53 staining. However, hypercellular activity was seen within the endotenon at 12 weeks postoperatively.
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U2 - 10.1016/S0266-7681(98)80017-X
DO - 10.1016/S0266-7681(98)80017-X
M3 - Article
C2 - 9821609
AN - SCOPUS:0031730348
SN - 1753-1934
VL - 23
SP - 627
EP - 632
JO - Journal of Hand Surgery: European Volume
JF - Journal of Hand Surgery: European Volume
IS - 5
ER -