Differential association of body mass index and fat distribution with three major histologic types of lung cancer: Evidence from a cohort of older women

Janet E Olson, Ping Yang, K. Schmitz, R. A. Vierkant, James R Cerhan, T. A. Sellers

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The Iowa Women's Health Study, a prospective cohort study of 41,836 Iowa women aged 55-69 years at baseline in 1986, reported that lung cancer was inversely associated with body mass index (BMI) and waist/hip ratio. Risk by histologic subtype was not examined. Through 1998, 596 cases of lung cancer were identified. After adjustment for established risk factors, women in the upper BMI quintile were at decreased risk of all lung cancer subtypes, especially squamous cell carcinoma; the highest versus the lowest quintile of BMI was associated with a relative risk of 0.22 (p-trend = 0.005). Conversely, the highest quintile of waist circumference was positively associated with small cell and squamous cell lung cancer (relative risks = 3.31 and 3.05, respectively). No association of waist circumference with risk of adenocarcinoma of the lung was found. There were too few cases of squamous cell and small cell carcinoma in never smokers to eliminate the possibility that these results are due to the residual effects of smoking. Alternatively, these results may reflect increased activation of chemicals from cigarette smoke among women with an increased waist circumference. Results suggest that waist circumference may be differentially associated with histologic subtypes of lung cancer.

Original languageEnglish (US)
Pages (from-to)606-615
Number of pages10
JournalAmerican Journal of Epidemiology
Volume156
Issue number7
DOIs
StatePublished - Oct 1 2002

Fingerprint

Waist Circumference
Lung Neoplasms
Body Mass Index
Fats
Squamous Cell Neoplasms
Small Cell Carcinoma
Waist-Hip Ratio
Women's Health
Smoke
Tobacco Products
Squamous Cell Carcinoma
Cohort Studies
Smoking
Epithelial Cells
Prospective Studies

Keywords

  • Body mass index
  • Cohort studies
  • Fat body
  • Histology
  • Lung neoplasms
  • Risk factors
  • Women

ASJC Scopus subject areas

  • Epidemiology

Cite this

@article{698ed68aad2147d5b1cc56ea70f1b8da,
title = "Differential association of body mass index and fat distribution with three major histologic types of lung cancer: Evidence from a cohort of older women",
abstract = "The Iowa Women's Health Study, a prospective cohort study of 41,836 Iowa women aged 55-69 years at baseline in 1986, reported that lung cancer was inversely associated with body mass index (BMI) and waist/hip ratio. Risk by histologic subtype was not examined. Through 1998, 596 cases of lung cancer were identified. After adjustment for established risk factors, women in the upper BMI quintile were at decreased risk of all lung cancer subtypes, especially squamous cell carcinoma; the highest versus the lowest quintile of BMI was associated with a relative risk of 0.22 (p-trend = 0.005). Conversely, the highest quintile of waist circumference was positively associated with small cell and squamous cell lung cancer (relative risks = 3.31 and 3.05, respectively). No association of waist circumference with risk of adenocarcinoma of the lung was found. There were too few cases of squamous cell and small cell carcinoma in never smokers to eliminate the possibility that these results are due to the residual effects of smoking. Alternatively, these results may reflect increased activation of chemicals from cigarette smoke among women with an increased waist circumference. Results suggest that waist circumference may be differentially associated with histologic subtypes of lung cancer.",
keywords = "Body mass index, Cohort studies, Fat body, Histology, Lung neoplasms, Risk factors, Women",
author = "Olson, {Janet E} and Ping Yang and K. Schmitz and Vierkant, {R. A.} and Cerhan, {James R} and Sellers, {T. A.}",
year = "2002",
month = "10",
day = "1",
doi = "10.1093/aje/kwf084",
language = "English (US)",
volume = "156",
pages = "606--615",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Differential association of body mass index and fat distribution with three major histologic types of lung cancer

T2 - Evidence from a cohort of older women

AU - Olson, Janet E

AU - Yang, Ping

AU - Schmitz, K.

AU - Vierkant, R. A.

AU - Cerhan, James R

AU - Sellers, T. A.

PY - 2002/10/1

Y1 - 2002/10/1

N2 - The Iowa Women's Health Study, a prospective cohort study of 41,836 Iowa women aged 55-69 years at baseline in 1986, reported that lung cancer was inversely associated with body mass index (BMI) and waist/hip ratio. Risk by histologic subtype was not examined. Through 1998, 596 cases of lung cancer were identified. After adjustment for established risk factors, women in the upper BMI quintile were at decreased risk of all lung cancer subtypes, especially squamous cell carcinoma; the highest versus the lowest quintile of BMI was associated with a relative risk of 0.22 (p-trend = 0.005). Conversely, the highest quintile of waist circumference was positively associated with small cell and squamous cell lung cancer (relative risks = 3.31 and 3.05, respectively). No association of waist circumference with risk of adenocarcinoma of the lung was found. There were too few cases of squamous cell and small cell carcinoma in never smokers to eliminate the possibility that these results are due to the residual effects of smoking. Alternatively, these results may reflect increased activation of chemicals from cigarette smoke among women with an increased waist circumference. Results suggest that waist circumference may be differentially associated with histologic subtypes of lung cancer.

AB - The Iowa Women's Health Study, a prospective cohort study of 41,836 Iowa women aged 55-69 years at baseline in 1986, reported that lung cancer was inversely associated with body mass index (BMI) and waist/hip ratio. Risk by histologic subtype was not examined. Through 1998, 596 cases of lung cancer were identified. After adjustment for established risk factors, women in the upper BMI quintile were at decreased risk of all lung cancer subtypes, especially squamous cell carcinoma; the highest versus the lowest quintile of BMI was associated with a relative risk of 0.22 (p-trend = 0.005). Conversely, the highest quintile of waist circumference was positively associated with small cell and squamous cell lung cancer (relative risks = 3.31 and 3.05, respectively). No association of waist circumference with risk of adenocarcinoma of the lung was found. There were too few cases of squamous cell and small cell carcinoma in never smokers to eliminate the possibility that these results are due to the residual effects of smoking. Alternatively, these results may reflect increased activation of chemicals from cigarette smoke among women with an increased waist circumference. Results suggest that waist circumference may be differentially associated with histologic subtypes of lung cancer.

KW - Body mass index

KW - Cohort studies

KW - Fat body

KW - Histology

KW - Lung neoplasms

KW - Risk factors

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=0036786594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036786594&partnerID=8YFLogxK

U2 - 10.1093/aje/kwf084

DO - 10.1093/aje/kwf084

M3 - Article

C2 - 12244029

AN - SCOPUS:0036786594

VL - 156

SP - 606

EP - 615

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 7

ER -