Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle

Nicholas J. Zyromski, Judy A. Duenes, Michael L. Kendrick, Karen D. Libsch, Roland Seiler, Toshiyuki Tanaka, Michael G. Sarr

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Early postoperative complications after small bowel transplantation (SBT) are likely mediated, at least in part, by dysmotility caused by the obligate disruption of extrinsic and enteric nerves in the graft. Adrenergic hypersensitivity of gut smooth muscle has been observed in some (but not all) segments of intestine in various experimental models of SBT, highlighting regional and species variability in response to denervation. Little is known about changes in canine longitudinal muscle after extrinsic denervation. Six dogs each underwent either complete extrinsic denervation of the jejunoileum or a control operation (transection and reanastomosis of the proximal jejunum and distal ileum). In vitro contractile response of longitudinal muscle strips to norepinephrine was evaluated at the time of the operation, and 2 weeks and 8 weeks later. After extrinsic denervation, the jejunal response to norepinephrine was preserved at all time points; however, the ileum displayed a decreased sensitivity to norepinephrine, an effect unmasked after intramural neural blockade with tetrodotoxin. These data support a potential for neurally mediated dysmotility after SBT and reinforce the differences in responses to extrinsic denervation between species, as well as differences within different regions and between anatomic segments of small intestine in the same species.

Original languageEnglish (US)
Pages (from-to)418-425
Number of pages8
JournalJournal of Gastrointestinal Surgery
Volume6
Issue number3
DOIs
StatePublished - 2002

Fingerprint

Denervation
Adrenergic Agents
Smooth Muscle
Canidae
Norepinephrine
Transplantation
Ileum
Muscles
Tetrodotoxin
Jejunum
Small Intestine
Intestines
Hypersensitivity
Theoretical Models
Dogs
Transplants

Keywords

  • Adrenergic denervation
  • Adrenergic innervation
  • Denervation
  • Extrinsic denervation
  • Motility
  • Small bowel transplantation
  • Smooth muscle

ASJC Scopus subject areas

  • Surgery

Cite this

Zyromski, N. J., Duenes, J. A., Kendrick, M. L., Libsch, K. D., Seiler, R., Tanaka, T., & Sarr, M. G. (2002). Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle. Journal of Gastrointestinal Surgery, 6(3), 418-425. https://doi.org/10.1016/S1091-255X(02)00006-9

Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle. / Zyromski, Nicholas J.; Duenes, Judy A.; Kendrick, Michael L.; Libsch, Karen D.; Seiler, Roland; Tanaka, Toshiyuki; Sarr, Michael G.

In: Journal of Gastrointestinal Surgery, Vol. 6, No. 3, 2002, p. 418-425.

Research output: Contribution to journalArticle

Zyromski, Nicholas J. ; Duenes, Judy A. ; Kendrick, Michael L. ; Libsch, Karen D. ; Seiler, Roland ; Tanaka, Toshiyuki ; Sarr, Michael G. / Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle. In: Journal of Gastrointestinal Surgery. 2002 ; Vol. 6, No. 3. pp. 418-425.
@article{a32e11bf5f4a43db923b98a7bd598a84,
title = "Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle",
abstract = "Early postoperative complications after small bowel transplantation (SBT) are likely mediated, at least in part, by dysmotility caused by the obligate disruption of extrinsic and enteric nerves in the graft. Adrenergic hypersensitivity of gut smooth muscle has been observed in some (but not all) segments of intestine in various experimental models of SBT, highlighting regional and species variability in response to denervation. Little is known about changes in canine longitudinal muscle after extrinsic denervation. Six dogs each underwent either complete extrinsic denervation of the jejunoileum or a control operation (transection and reanastomosis of the proximal jejunum and distal ileum). In vitro contractile response of longitudinal muscle strips to norepinephrine was evaluated at the time of the operation, and 2 weeks and 8 weeks later. After extrinsic denervation, the jejunal response to norepinephrine was preserved at all time points; however, the ileum displayed a decreased sensitivity to norepinephrine, an effect unmasked after intramural neural blockade with tetrodotoxin. These data support a potential for neurally mediated dysmotility after SBT and reinforce the differences in responses to extrinsic denervation between species, as well as differences within different regions and between anatomic segments of small intestine in the same species.",
keywords = "Adrenergic denervation, Adrenergic innervation, Denervation, Extrinsic denervation, Motility, Small bowel transplantation, Smooth muscle",
author = "Zyromski, {Nicholas J.} and Duenes, {Judy A.} and Kendrick, {Michael L.} and Libsch, {Karen D.} and Roland Seiler and Toshiyuki Tanaka and Sarr, {Michael G.}",
year = "2002",
doi = "10.1016/S1091-255X(02)00006-9",
language = "English (US)",
volume = "6",
pages = "418--425",
journal = "Journal of Gastrointestinal Surgery",
issn = "1091-255X",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle

AU - Zyromski, Nicholas J.

AU - Duenes, Judy A.

AU - Kendrick, Michael L.

AU - Libsch, Karen D.

AU - Seiler, Roland

AU - Tanaka, Toshiyuki

AU - Sarr, Michael G.

PY - 2002

Y1 - 2002

N2 - Early postoperative complications after small bowel transplantation (SBT) are likely mediated, at least in part, by dysmotility caused by the obligate disruption of extrinsic and enteric nerves in the graft. Adrenergic hypersensitivity of gut smooth muscle has been observed in some (but not all) segments of intestine in various experimental models of SBT, highlighting regional and species variability in response to denervation. Little is known about changes in canine longitudinal muscle after extrinsic denervation. Six dogs each underwent either complete extrinsic denervation of the jejunoileum or a control operation (transection and reanastomosis of the proximal jejunum and distal ileum). In vitro contractile response of longitudinal muscle strips to norepinephrine was evaluated at the time of the operation, and 2 weeks and 8 weeks later. After extrinsic denervation, the jejunal response to norepinephrine was preserved at all time points; however, the ileum displayed a decreased sensitivity to norepinephrine, an effect unmasked after intramural neural blockade with tetrodotoxin. These data support a potential for neurally mediated dysmotility after SBT and reinforce the differences in responses to extrinsic denervation between species, as well as differences within different regions and between anatomic segments of small intestine in the same species.

AB - Early postoperative complications after small bowel transplantation (SBT) are likely mediated, at least in part, by dysmotility caused by the obligate disruption of extrinsic and enteric nerves in the graft. Adrenergic hypersensitivity of gut smooth muscle has been observed in some (but not all) segments of intestine in various experimental models of SBT, highlighting regional and species variability in response to denervation. Little is known about changes in canine longitudinal muscle after extrinsic denervation. Six dogs each underwent either complete extrinsic denervation of the jejunoileum or a control operation (transection and reanastomosis of the proximal jejunum and distal ileum). In vitro contractile response of longitudinal muscle strips to norepinephrine was evaluated at the time of the operation, and 2 weeks and 8 weeks later. After extrinsic denervation, the jejunal response to norepinephrine was preserved at all time points; however, the ileum displayed a decreased sensitivity to norepinephrine, an effect unmasked after intramural neural blockade with tetrodotoxin. These data support a potential for neurally mediated dysmotility after SBT and reinforce the differences in responses to extrinsic denervation between species, as well as differences within different regions and between anatomic segments of small intestine in the same species.

KW - Adrenergic denervation

KW - Adrenergic innervation

KW - Denervation

KW - Extrinsic denervation

KW - Motility

KW - Small bowel transplantation

KW - Smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=0036582635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036582635&partnerID=8YFLogxK

U2 - 10.1016/S1091-255X(02)00006-9

DO - 10.1016/S1091-255X(02)00006-9

M3 - Article

C2 - 12022995

AN - SCOPUS:0036582635

VL - 6

SP - 418

EP - 425

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 3

ER -