Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle

Nicholas J. Zyromski, Judy A. Duenes, Michael L. Kendrick, Karen D. Libsch, Roland Seiler, Toshiyuki Tanaka, Michael G. Sarr

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Early postoperative complications after small bowel transplantation (SBT) are likely mediated, at least in part, by dysmotility caused by the obligate disruption of extrinsic and enteric nerves in the graft. Adrenergic hypersensitivity of gut smooth muscle has been observed in some (but not all) segments of intestine in various experimental models of SBT, highlighting regional and species variability in response to denervation. Little is known about changes in canine longitudinal muscle after extrinsic denervation. Six dogs each underwent either complete extrinsic denervation of the jejunoileum or a control operation (transection and reanastomosis of the proximal jejunum and distal ileum). In vitro contractile response of longitudinal muscle strips to norepinephrine was evaluated at the time of the operation, and 2 weeks and 8 weeks later. After extrinsic denervation, the jejunal response to norepinephrine was preserved at all time points; however, the ileum displayed a decreased sensitivity to norepinephrine, an effect unmasked after intramural neural blockade with tetrodotoxin. These data support a potential for neurally mediated dysmotility after SBT and reinforce the differences in responses to extrinsic denervation between species, as well as differences within different regions and between anatomic segments of small intestine in the same species.

Original languageEnglish (US)
Pages (from-to)418-425
Number of pages8
JournalJournal of Gastrointestinal Surgery
Volume6
Issue number3
DOIs
StatePublished - Dec 1 2002

Keywords

  • Adrenergic denervation
  • Adrenergic innervation
  • Denervation
  • Extrinsic denervation
  • Motility
  • Small bowel transplantation
  • Smooth muscle

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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    Zyromski, N. J., Duenes, J. A., Kendrick, M. L., Libsch, K. D., Seiler, R., Tanaka, T., & Sarr, M. G. (2002). Differential adrenergic response to extrinsic denervation in canine longitudinal jejunal and ileal smooth muscle. Journal of Gastrointestinal Surgery, 6(3), 418-425. https://doi.org/10.1016/S1091-255X(02)00006-9