Different T cell receptor signals determine CD8+ memory versus effector development

Emma Teixeiro, Mark A. Daniels, Sara E. Hamilton, Adam G. Schrum, Rafael Bragado, Stephen C. Jameson, Ed Palmer

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Abstract

Following infection, naïve CD8+ T cells bearing pathogen-specific T cell receptors (TCRs) differentiate into a mixed population of short-lived effector and long-lived memory T cells to mediate an adaptive immune response. How the TCR regulates memory T cell development has remained elusive. Using a mutant TCR transgenic model, we found that point mutations in the TCR β transmembrane domain (βTMD) impair the development and function of CD8+ memory T cells without affecting primary effector T cell responses. Mutant T cells are deficient in polarizing the TCR and in organizing the nuclear factor κB signal at the immunological synapse. Thus, effector and memory states of CD8+ T cells are separable fates, determined by differential TCR signaling.

Original languageEnglish (US)
Pages (from-to)502-505
Number of pages4
JournalScience
Volume323
Issue number5913
DOIs
StatePublished - Jan 23 2009

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Cite this

Teixeiro, E., Daniels, M. A., Hamilton, S. E., Schrum, A. G., Bragado, R., Jameson, S. C., & Palmer, E. (2009). Different T cell receptor signals determine CD8+ memory versus effector development. Science, 323(5913), 502-505. https://doi.org/10.1126/science.1163612