Different T cell receptor signals determine CD8+ memory versus effector development

Emma Teixeiro, Mark A. Daniels, Sara E. Hamilton, Adam G. Schrum, Rafael Bragado, Stephen C. Jameson, Ed Palmer

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Following infection, naïve CD8+ T cells bearing pathogen-specific T cell receptors (TCRs) differentiate into a mixed population of short-lived effector and long-lived memory T cells to mediate an adaptive immune response. How the TCR regulates memory T cell development has remained elusive. Using a mutant TCR transgenic model, we found that point mutations in the TCR β transmembrane domain (βTMD) impair the development and function of CD8+ memory T cells without affecting primary effector T cell responses. Mutant T cells are deficient in polarizing the TCR and in organizing the nuclear factor κB signal at the immunological synapse. Thus, effector and memory states of CD8+ T cells are separable fates, determined by differential TCR signaling.

Original languageEnglish (US)
Pages (from-to)502-505
Number of pages4
JournalScience
Volume323
Issue number5913
DOIs
StatePublished - Jan 23 2009

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T-Cell Antigen Receptor
T-Lymphocytes
Immunological Synapses
Adaptive Immunity
Point Mutation
Infection
Population

ASJC Scopus subject areas

  • General

Cite this

Teixeiro, E., Daniels, M. A., Hamilton, S. E., Schrum, A. G., Bragado, R., Jameson, S. C., & Palmer, E. (2009). Different T cell receptor signals determine CD8+ memory versus effector development. Science, 323(5913), 502-505. https://doi.org/10.1126/science.1163612

Different T cell receptor signals determine CD8+ memory versus effector development. / Teixeiro, Emma; Daniels, Mark A.; Hamilton, Sara E.; Schrum, Adam G.; Bragado, Rafael; Jameson, Stephen C.; Palmer, Ed.

In: Science, Vol. 323, No. 5913, 23.01.2009, p. 502-505.

Research output: Contribution to journalArticle

Teixeiro, E, Daniels, MA, Hamilton, SE, Schrum, AG, Bragado, R, Jameson, SC & Palmer, E 2009, 'Different T cell receptor signals determine CD8+ memory versus effector development', Science, vol. 323, no. 5913, pp. 502-505. https://doi.org/10.1126/science.1163612
Teixeiro E, Daniels MA, Hamilton SE, Schrum AG, Bragado R, Jameson SC et al. Different T cell receptor signals determine CD8+ memory versus effector development. Science. 2009 Jan 23;323(5913):502-505. https://doi.org/10.1126/science.1163612
Teixeiro, Emma ; Daniels, Mark A. ; Hamilton, Sara E. ; Schrum, Adam G. ; Bragado, Rafael ; Jameson, Stephen C. ; Palmer, Ed. / Different T cell receptor signals determine CD8+ memory versus effector development. In: Science. 2009 ; Vol. 323, No. 5913. pp. 502-505.
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