Different approaches in the gene therapy of cancer

M. J. Gough, R. G. Vile

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The requirements of gene therapy for cancer are distinct from those of gene therapy for hereditary monogenic diseases. In cancer the aim is to kill, not cure tumour cells. Also issues such as duration of gene expression and immunogenicity of vector systems are of less relevance than efficiency of delivery to all tumour cells. In this light, we discuss the vector systems currently available and the methods to target transgenes to tumour cells. In view of the current limitations in both vector systems and targeting of tumours, we discuss the strategies that may be applied to increase the effectiveness of inefficient delivery, such as immune activation, bystander cytotoxicity and replication-competent viruses.

Original languageEnglish (US)
Pages (from-to)225-236
Number of pages12
JournalFORUM - Trends in Experimental and Clinical Medicine
Volume9
Issue number3
StatePublished - Nov 3 1999

Keywords

  • Cancer
  • Gene therapy
  • Immunotherapy
  • Replication-competent
  • Suicide gene
  • Targeting
  • Vector

ASJC Scopus subject areas

  • Medicine(all)

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