Differences in the distribution of cytogenetic subtypes between multiple myeloma patients with and without a family history of monoclonal gammopathy and multiple myeloma

Alexandra J. Greenberg, Margot Cousin, Shaji Kumar, Rhett P. Ketterling, Ryan A. Knudson, Dirk Larson, Colin Colby, Christopher Scott, Celine M. Vachon, S. Vincent Rajkumar

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We previously reported an increased risk of monoclonal gammopathy of undetermined significance (MGUS) in first-degree relatives of MGUS and multiple myeloma patients. Here, we examine whether primary cytogenetic categories of myeloma differ between patients with and without a family history of MGUS or myeloma. We studied 201 myeloma patients with available data on family history and molecular cytogenetic classification. Myeloma with trisomies was more common in probands who had an affected first-degree relative with MGUS or myeloma compared with those without a family history (46.9% vs. 33.5%, P = 0.125); however, the difference was not statistically significant. Additional studies on the cytogenetic types of myeloma associated with familial tendency are needed. 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalEuropean Journal of Haematology
Volume91
Issue number3
DOIs
StatePublished - Sep 2013

Keywords

  • Cytogenetics
  • Family history
  • Monoclonal gammopathy of undetermined significance
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Differences in the distribution of cytogenetic subtypes between multiple myeloma patients with and without a family history of monoclonal gammopathy and multiple myeloma'. Together they form a unique fingerprint.

  • Cite this