Differences in the distribution of cytogenetic subtypes between multiple myeloma patients with and without a family history of monoclonal gammopathy and multiple myeloma

Alexandra J. Greenberg, Margot Cousin, Shaji K Kumar, Rhett P. Ketterling, Ryan A. Knudson, Dirk Larson, Colin Colby, Christopher Scott, Celine M Vachon, S Vincent Rajkumar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We previously reported an increased risk of monoclonal gammopathy of undetermined significance (MGUS) in first-degree relatives of MGUS and multiple myeloma patients. Here, we examine whether primary cytogenetic categories of myeloma differ between patients with and without a family history of MGUS or myeloma. We studied 201 myeloma patients with available data on family history and molecular cytogenetic classification. Myeloma with trisomies was more common in probands who had an affected first-degree relative with MGUS or myeloma compared with those without a family history (46.9% vs. 33.5%, P = 0.125); however, the difference was not statistically significant. Additional studies on the cytogenetic types of myeloma associated with familial tendency are needed. 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalEuropean Journal of Haematology
Volume91
Issue number3
DOIs
StatePublished - Sep 2013

Fingerprint

Monoclonal Gammopathy of Undetermined Significance
Paraproteinemias
Multiple Myeloma
Cytogenetics
Nuclear Family
Trisomy

Keywords

  • Cytogenetics
  • Family history
  • Monoclonal gammopathy of undetermined significance
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology

Cite this

Differences in the distribution of cytogenetic subtypes between multiple myeloma patients with and without a family history of monoclonal gammopathy and multiple myeloma. / Greenberg, Alexandra J.; Cousin, Margot; Kumar, Shaji K; Ketterling, Rhett P.; Knudson, Ryan A.; Larson, Dirk; Colby, Colin; Scott, Christopher; Vachon, Celine M; Rajkumar, S Vincent.

In: European Journal of Haematology, Vol. 91, No. 3, 09.2013, p. 193-195.

Research output: Contribution to journalArticle

Greenberg, Alexandra J. ; Cousin, Margot ; Kumar, Shaji K ; Ketterling, Rhett P. ; Knudson, Ryan A. ; Larson, Dirk ; Colby, Colin ; Scott, Christopher ; Vachon, Celine M ; Rajkumar, S Vincent. / Differences in the distribution of cytogenetic subtypes between multiple myeloma patients with and without a family history of monoclonal gammopathy and multiple myeloma. In: European Journal of Haematology. 2013 ; Vol. 91, No. 3. pp. 193-195.
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