Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles

Lawrence F. Bielak, PanFong Yu, Kathleen A. Ryan, John A. Rumberger, Patrick F. Sheedy, Stephen T Turner, Wendy Post, Alan R. Shuldiner, Braxton D. Mitchell, Patricia A. Peyser

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Comparison of atherosclerosis and its risk factors among diverse populations may provide insights into the pathogenesis of the disease. We investigated differences in traditional coronary artery disease (CAD) risk factors and presence and quantity of coronary artery calcification (CAC), a marker of subclinical coronary atherosclerosis, between two diverse non-Hispanic white populations living in the US. Methods and results: Members of the Old Order Amish (OOA), a unique culture with a physically active rural lifestyle who rarely use prescription medications, were compared to another non-Hispanic white population with a more typical US lifestyle, Epidemiology of Coronary Artery Calcification (ECAC), Study participants from Rochester, Minnesota. Although age- and sex-adjusted presence and quantity of CAC in those with detectable CAC were similar between study groups, there were significant differences in the distribution of many traditional CAD risk factors. OOA had significantly less abdominal adiposity and history of cigarette smoking but a less advantageous lipid profile than ECAC participants. Importantly, after adjusting for CAD risk factors, presence of CAC and quantity of CAC among those with detectable CAC were significantly higher among OOA than ECAC participants. Conclusions: Identification of factors contributing to differences in subclinical disease across groups could increase our understanding of mechanisms for coronary atherosclerosis.

Original languageEnglish (US)
Pages (from-to)888-895
Number of pages8
JournalAtherosclerosis
Volume196
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Life Style
Coronary Vessels
Amish
Coronary Artery Disease
Population
Epidemiology
Adiposity
Prescriptions
Atherosclerosis
Smoking
Lipids

Keywords

  • Atherosclerosis
  • Coronary artery calcification
  • Epidemiology
  • Imaging
  • Lifestyle
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles. / Bielak, Lawrence F.; Yu, PanFong; Ryan, Kathleen A.; Rumberger, John A.; Sheedy, Patrick F.; Turner, Stephen T; Post, Wendy; Shuldiner, Alan R.; Mitchell, Braxton D.; Peyser, Patricia A.

In: Atherosclerosis, Vol. 196, No. 2, 02.2008, p. 888-895.

Research output: Contribution to journalArticle

Bielak, LF, Yu, P, Ryan, KA, Rumberger, JA, Sheedy, PF, Turner, ST, Post, W, Shuldiner, AR, Mitchell, BD & Peyser, PA 2008, 'Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles', Atherosclerosis, vol. 196, no. 2, pp. 888-895. https://doi.org/10.1016/j.atherosclerosis.2007.01.041
Bielak, Lawrence F. ; Yu, PanFong ; Ryan, Kathleen A. ; Rumberger, John A. ; Sheedy, Patrick F. ; Turner, Stephen T ; Post, Wendy ; Shuldiner, Alan R. ; Mitchell, Braxton D. ; Peyser, Patricia A. / Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles. In: Atherosclerosis. 2008 ; Vol. 196, No. 2. pp. 888-895.
@article{eae0cc66f64b44a59490dff80d364d29,
title = "Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles",
abstract = "Background: Comparison of atherosclerosis and its risk factors among diverse populations may provide insights into the pathogenesis of the disease. We investigated differences in traditional coronary artery disease (CAD) risk factors and presence and quantity of coronary artery calcification (CAC), a marker of subclinical coronary atherosclerosis, between two diverse non-Hispanic white populations living in the US. Methods and results: Members of the Old Order Amish (OOA), a unique culture with a physically active rural lifestyle who rarely use prescription medications, were compared to another non-Hispanic white population with a more typical US lifestyle, Epidemiology of Coronary Artery Calcification (ECAC), Study participants from Rochester, Minnesota. Although age- and sex-adjusted presence and quantity of CAC in those with detectable CAC were similar between study groups, there were significant differences in the distribution of many traditional CAD risk factors. OOA had significantly less abdominal adiposity and history of cigarette smoking but a less advantageous lipid profile than ECAC participants. Importantly, after adjusting for CAD risk factors, presence of CAC and quantity of CAC among those with detectable CAC were significantly higher among OOA than ECAC participants. Conclusions: Identification of factors contributing to differences in subclinical disease across groups could increase our understanding of mechanisms for coronary atherosclerosis.",
keywords = "Atherosclerosis, Coronary artery calcification, Epidemiology, Imaging, Lifestyle, Risk factors",
author = "Bielak, {Lawrence F.} and PanFong Yu and Ryan, {Kathleen A.} and Rumberger, {John A.} and Sheedy, {Patrick F.} and Turner, {Stephen T} and Wendy Post and Shuldiner, {Alan R.} and Mitchell, {Braxton D.} and Peyser, {Patricia A.}",
year = "2008",
month = "2",
doi = "10.1016/j.atherosclerosis.2007.01.041",
language = "English (US)",
volume = "196",
pages = "888--895",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles

AU - Bielak, Lawrence F.

AU - Yu, PanFong

AU - Ryan, Kathleen A.

AU - Rumberger, John A.

AU - Sheedy, Patrick F.

AU - Turner, Stephen T

AU - Post, Wendy

AU - Shuldiner, Alan R.

AU - Mitchell, Braxton D.

AU - Peyser, Patricia A.

PY - 2008/2

Y1 - 2008/2

N2 - Background: Comparison of atherosclerosis and its risk factors among diverse populations may provide insights into the pathogenesis of the disease. We investigated differences in traditional coronary artery disease (CAD) risk factors and presence and quantity of coronary artery calcification (CAC), a marker of subclinical coronary atherosclerosis, between two diverse non-Hispanic white populations living in the US. Methods and results: Members of the Old Order Amish (OOA), a unique culture with a physically active rural lifestyle who rarely use prescription medications, were compared to another non-Hispanic white population with a more typical US lifestyle, Epidemiology of Coronary Artery Calcification (ECAC), Study participants from Rochester, Minnesota. Although age- and sex-adjusted presence and quantity of CAC in those with detectable CAC were similar between study groups, there were significant differences in the distribution of many traditional CAD risk factors. OOA had significantly less abdominal adiposity and history of cigarette smoking but a less advantageous lipid profile than ECAC participants. Importantly, after adjusting for CAD risk factors, presence of CAC and quantity of CAC among those with detectable CAC were significantly higher among OOA than ECAC participants. Conclusions: Identification of factors contributing to differences in subclinical disease across groups could increase our understanding of mechanisms for coronary atherosclerosis.

AB - Background: Comparison of atherosclerosis and its risk factors among diverse populations may provide insights into the pathogenesis of the disease. We investigated differences in traditional coronary artery disease (CAD) risk factors and presence and quantity of coronary artery calcification (CAC), a marker of subclinical coronary atherosclerosis, between two diverse non-Hispanic white populations living in the US. Methods and results: Members of the Old Order Amish (OOA), a unique culture with a physically active rural lifestyle who rarely use prescription medications, were compared to another non-Hispanic white population with a more typical US lifestyle, Epidemiology of Coronary Artery Calcification (ECAC), Study participants from Rochester, Minnesota. Although age- and sex-adjusted presence and quantity of CAC in those with detectable CAC were similar between study groups, there were significant differences in the distribution of many traditional CAD risk factors. OOA had significantly less abdominal adiposity and history of cigarette smoking but a less advantageous lipid profile than ECAC participants. Importantly, after adjusting for CAD risk factors, presence of CAC and quantity of CAC among those with detectable CAC were significantly higher among OOA than ECAC participants. Conclusions: Identification of factors contributing to differences in subclinical disease across groups could increase our understanding of mechanisms for coronary atherosclerosis.

KW - Atherosclerosis

KW - Coronary artery calcification

KW - Epidemiology

KW - Imaging

KW - Lifestyle

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=38349195038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349195038&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2007.01.041

DO - 10.1016/j.atherosclerosis.2007.01.041

M3 - Article

C2 - 17368463

AN - SCOPUS:38349195038

VL - 196

SP - 888

EP - 895

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -