Differences in organ system of distant metastasis by renal cell carcinoma subtype

Nathan E. Hoffmann, Michael D. Gillett, John C. Cheville, Christine M. Lohse, Bradley C. Leibovich, Michael L. Blute

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Purpose; The majority of the published data regarding the rates of renal cell carcinoma metastasis to specific locations has examined renal cell carcinoma as a whole. We evaluated site of distant metastasis by renal cell carcinoma histological subtype. Materials and Methods; We studied 910 patients treated with radical nephrectomy for clear cell, papillary or chromophobe renal cell carcinoma at the Mayo Clinic between 1970 and 2000 who had distant metastasis at nephrectomy or who had metastasis during followup. The sites of metastases were compared by histological subtype using the chi-square and Fisher exact tests. Results; There were 853 (94%) patients with clear cell, 39 (4%) with papillary and 18 (2%) with chromophobe renal cell carcinoma. Median followup for the 65 patients who were still alive at last followup was 11.6 years. Patients with clear cell renal cell carcinoma were more likely to have metastasis to the lungs (53.6%) compared to those with papillary (33.3%) and chromophobe (33.3%) renal cell carcinoma (p = 0.012). Patients with chromophobe renal cell carcinoma were more likely to have metastasis to the liver compared to those with clear cell renal cell carcinoma (33.3% vs 9.7%, p = 0.007), but there was not a statistically significantly difference in the incidence of liver metastases between patients with chromophobe and papillary renal cell carcinoma (33.3% vs 18.0%, p = 0.308). Conclusions; Site of distant metastasis varies significantly by renal cell carcinoma histological subtype. Patients with clear cell renal cell carcinoma are more likely to have metastasis to the lungs while patients with chromophobe renal cell carcinoma are more likely to experience liver metastasis.

Original languageEnglish (US)
Pages (from-to)474-477
Number of pages4
JournalJournal of Urology
Volume179
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Renal Cell Carcinoma
Neoplasm Metastasis
Nephrectomy
Liver
Lung

Keywords

  • Carcinoma, renal cell
  • Neoplasm metastasis

ASJC Scopus subject areas

  • Medicine(all)
  • Urology

Cite this

Hoffmann, N. E., Gillett, M. D., Cheville, J. C., Lohse, C. M., Leibovich, B. C., & Blute, M. L. (2008). Differences in organ system of distant metastasis by renal cell carcinoma subtype. Journal of Urology, 179(2), 474-477. https://doi.org/10.1016/j.juro.2007.09.036

Differences in organ system of distant metastasis by renal cell carcinoma subtype. / Hoffmann, Nathan E.; Gillett, Michael D.; Cheville, John C.; Lohse, Christine M.; Leibovich, Bradley C.; Blute, Michael L.

In: Journal of Urology, Vol. 179, No. 2, 02.2008, p. 474-477.

Research output: Contribution to journalArticle

Hoffmann, NE, Gillett, MD, Cheville, JC, Lohse, CM, Leibovich, BC & Blute, ML 2008, 'Differences in organ system of distant metastasis by renal cell carcinoma subtype', Journal of Urology, vol. 179, no. 2, pp. 474-477. https://doi.org/10.1016/j.juro.2007.09.036
Hoffmann NE, Gillett MD, Cheville JC, Lohse CM, Leibovich BC, Blute ML. Differences in organ system of distant metastasis by renal cell carcinoma subtype. Journal of Urology. 2008 Feb;179(2):474-477. https://doi.org/10.1016/j.juro.2007.09.036
Hoffmann, Nathan E. ; Gillett, Michael D. ; Cheville, John C. ; Lohse, Christine M. ; Leibovich, Bradley C. ; Blute, Michael L. / Differences in organ system of distant metastasis by renal cell carcinoma subtype. In: Journal of Urology. 2008 ; Vol. 179, No. 2. pp. 474-477.
@article{1b004e504959456e80d723b52444b728,
title = "Differences in organ system of distant metastasis by renal cell carcinoma subtype",
abstract = "Purpose; The majority of the published data regarding the rates of renal cell carcinoma metastasis to specific locations has examined renal cell carcinoma as a whole. We evaluated site of distant metastasis by renal cell carcinoma histological subtype. Materials and Methods; We studied 910 patients treated with radical nephrectomy for clear cell, papillary or chromophobe renal cell carcinoma at the Mayo Clinic between 1970 and 2000 who had distant metastasis at nephrectomy or who had metastasis during followup. The sites of metastases were compared by histological subtype using the chi-square and Fisher exact tests. Results; There were 853 (94{\%}) patients with clear cell, 39 (4{\%}) with papillary and 18 (2{\%}) with chromophobe renal cell carcinoma. Median followup for the 65 patients who were still alive at last followup was 11.6 years. Patients with clear cell renal cell carcinoma were more likely to have metastasis to the lungs (53.6{\%}) compared to those with papillary (33.3{\%}) and chromophobe (33.3{\%}) renal cell carcinoma (p = 0.012). Patients with chromophobe renal cell carcinoma were more likely to have metastasis to the liver compared to those with clear cell renal cell carcinoma (33.3{\%} vs 9.7{\%}, p = 0.007), but there was not a statistically significantly difference in the incidence of liver metastases between patients with chromophobe and papillary renal cell carcinoma (33.3{\%} vs 18.0{\%}, p = 0.308). Conclusions; Site of distant metastasis varies significantly by renal cell carcinoma histological subtype. Patients with clear cell renal cell carcinoma are more likely to have metastasis to the lungs while patients with chromophobe renal cell carcinoma are more likely to experience liver metastasis.",
keywords = "Carcinoma, renal cell, Neoplasm metastasis",
author = "Hoffmann, {Nathan E.} and Gillett, {Michael D.} and Cheville, {John C.} and Lohse, {Christine M.} and Leibovich, {Bradley C.} and Blute, {Michael L.}",
year = "2008",
month = "2",
doi = "10.1016/j.juro.2007.09.036",
language = "English (US)",
volume = "179",
pages = "474--477",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Differences in organ system of distant metastasis by renal cell carcinoma subtype

AU - Hoffmann, Nathan E.

AU - Gillett, Michael D.

AU - Cheville, John C.

AU - Lohse, Christine M.

AU - Leibovich, Bradley C.

AU - Blute, Michael L.

PY - 2008/2

Y1 - 2008/2

N2 - Purpose; The majority of the published data regarding the rates of renal cell carcinoma metastasis to specific locations has examined renal cell carcinoma as a whole. We evaluated site of distant metastasis by renal cell carcinoma histological subtype. Materials and Methods; We studied 910 patients treated with radical nephrectomy for clear cell, papillary or chromophobe renal cell carcinoma at the Mayo Clinic between 1970 and 2000 who had distant metastasis at nephrectomy or who had metastasis during followup. The sites of metastases were compared by histological subtype using the chi-square and Fisher exact tests. Results; There were 853 (94%) patients with clear cell, 39 (4%) with papillary and 18 (2%) with chromophobe renal cell carcinoma. Median followup for the 65 patients who were still alive at last followup was 11.6 years. Patients with clear cell renal cell carcinoma were more likely to have metastasis to the lungs (53.6%) compared to those with papillary (33.3%) and chromophobe (33.3%) renal cell carcinoma (p = 0.012). Patients with chromophobe renal cell carcinoma were more likely to have metastasis to the liver compared to those with clear cell renal cell carcinoma (33.3% vs 9.7%, p = 0.007), but there was not a statistically significantly difference in the incidence of liver metastases between patients with chromophobe and papillary renal cell carcinoma (33.3% vs 18.0%, p = 0.308). Conclusions; Site of distant metastasis varies significantly by renal cell carcinoma histological subtype. Patients with clear cell renal cell carcinoma are more likely to have metastasis to the lungs while patients with chromophobe renal cell carcinoma are more likely to experience liver metastasis.

AB - Purpose; The majority of the published data regarding the rates of renal cell carcinoma metastasis to specific locations has examined renal cell carcinoma as a whole. We evaluated site of distant metastasis by renal cell carcinoma histological subtype. Materials and Methods; We studied 910 patients treated with radical nephrectomy for clear cell, papillary or chromophobe renal cell carcinoma at the Mayo Clinic between 1970 and 2000 who had distant metastasis at nephrectomy or who had metastasis during followup. The sites of metastases were compared by histological subtype using the chi-square and Fisher exact tests. Results; There were 853 (94%) patients with clear cell, 39 (4%) with papillary and 18 (2%) with chromophobe renal cell carcinoma. Median followup for the 65 patients who were still alive at last followup was 11.6 years. Patients with clear cell renal cell carcinoma were more likely to have metastasis to the lungs (53.6%) compared to those with papillary (33.3%) and chromophobe (33.3%) renal cell carcinoma (p = 0.012). Patients with chromophobe renal cell carcinoma were more likely to have metastasis to the liver compared to those with clear cell renal cell carcinoma (33.3% vs 9.7%, p = 0.007), but there was not a statistically significantly difference in the incidence of liver metastases between patients with chromophobe and papillary renal cell carcinoma (33.3% vs 18.0%, p = 0.308). Conclusions; Site of distant metastasis varies significantly by renal cell carcinoma histological subtype. Patients with clear cell renal cell carcinoma are more likely to have metastasis to the lungs while patients with chromophobe renal cell carcinoma are more likely to experience liver metastasis.

KW - Carcinoma, renal cell

KW - Neoplasm metastasis

UR - http://www.scopus.com/inward/record.url?scp=38849200581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38849200581&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2007.09.036

DO - 10.1016/j.juro.2007.09.036

M3 - Article

VL - 179

SP - 474

EP - 477

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -