Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis)

Deepak K. Gupta, Lori B. Daniels, Susan Cheng, Christopher R. deFilippi, Michael H. Criqui, Alan S. Maisel, Joao A. Lima, Hossein Bahrami, Philip Greenland, Mary Cushman, Russell Tracy, David Siscovick, Alain G. Bertoni, Valentina Cannone, John C Jr. Burnett, John Jeffrey Carr, Thomas J. Wang

Research output: Contribution to journalArticle

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Abstract

Natriuretic peptides (NP) are cardiac-derived hormones with favorable cardiometabolic actions. Low NP levels are associated with increased risks of hypertension and diabetes mellitus, conditions with variable prevalence by race and ethnicity. Heritable factors underlie a significant proportion of the interindividual variation in NP concentrations, but the specific influences of race and ancestry are unknown. In 5597 individuals (40% white, 24% black, 23% Hispanic, and 13% Chinese) without prevalent cardiovascular disease at baseline in the Multi-Ethnic Study of Atherosclerosis, multivariable linear regression and restricted cubic splines were used to estimate differences in serum N-terminal pro B-type natriuretic peptide (NT-proBNP) levels according to, ethnicity, and ancestry. Ancestry was determined using genetic ancestry informative markers. NT-proBNP concentrations differed significantly by race and ethnicity (black, median 43 pg/ml [interquartile range 17 to 94], Chinese 43 [17 to 90], Hispanic 53 [23 to 107], white 68 [34 to 136]; p = 0.0001). In multivariable models, NT-proBNP was 44% lower (95% confidence interval -48 to -40) in black and 46% lower (-50 to -41) in Chinese, compared with white individuals. Hispanic individuals had intermediate concentrations. Self-identified blacks and Hispanics were the most genetically admixed. Among self-identified black individuals, a 20% increase in genetic European ancestry was associated with 12% higher (1% to 23%) NT-proBNP. Among Hispanic individuals, genetic European and African ancestry were positively and negatively associated with NT-proBNP levels, respectively. In conclusion, NT-proBNP levels differ according to race and ethnicity, with the lowest concentrations in black and Chinese individuals. Racial and ethnic differences in NT-proBNP may have a genetic basis, with European and African ancestry associated with higher and lower NT-proBNP concentrations, respectively.

Original languageEnglish (US)
JournalAmerican Journal of Cardiology
DOIs
StateAccepted/In press - 2017

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Natriuretic Peptides
Brain Natriuretic Peptide
Atherosclerosis
Hispanic Americans
Linear Models
Diabetes Mellitus
Cardiovascular Diseases
Hormones
Confidence Intervals
Hypertension
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Gupta, D. K., Daniels, L. B., Cheng, S., deFilippi, C. R., Criqui, M. H., Maisel, A. S., ... Wang, T. J. (Accepted/In press). Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis). American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2017.06.030

Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis). / Gupta, Deepak K.; Daniels, Lori B.; Cheng, Susan; deFilippi, Christopher R.; Criqui, Michael H.; Maisel, Alan S.; Lima, Joao A.; Bahrami, Hossein; Greenland, Philip; Cushman, Mary; Tracy, Russell; Siscovick, David; Bertoni, Alain G.; Cannone, Valentina; Burnett, John C Jr.; Carr, John Jeffrey; Wang, Thomas J.

In: American Journal of Cardiology, 2017.

Research output: Contribution to journalArticle

Gupta, DK, Daniels, LB, Cheng, S, deFilippi, CR, Criqui, MH, Maisel, AS, Lima, JA, Bahrami, H, Greenland, P, Cushman, M, Tracy, R, Siscovick, D, Bertoni, AG, Cannone, V, Burnett, JCJ, Carr, JJ & Wang, TJ 2017, 'Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis)', American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2017.06.030
Gupta, Deepak K. ; Daniels, Lori B. ; Cheng, Susan ; deFilippi, Christopher R. ; Criqui, Michael H. ; Maisel, Alan S. ; Lima, Joao A. ; Bahrami, Hossein ; Greenland, Philip ; Cushman, Mary ; Tracy, Russell ; Siscovick, David ; Bertoni, Alain G. ; Cannone, Valentina ; Burnett, John C Jr. ; Carr, John Jeffrey ; Wang, Thomas J. / Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis). In: American Journal of Cardiology. 2017.
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abstract = "Natriuretic peptides (NP) are cardiac-derived hormones with favorable cardiometabolic actions. Low NP levels are associated with increased risks of hypertension and diabetes mellitus, conditions with variable prevalence by race and ethnicity. Heritable factors underlie a significant proportion of the interindividual variation in NP concentrations, but the specific influences of race and ancestry are unknown. In 5597 individuals (40{\%} white, 24{\%} black, 23{\%} Hispanic, and 13{\%} Chinese) without prevalent cardiovascular disease at baseline in the Multi-Ethnic Study of Atherosclerosis, multivariable linear regression and restricted cubic splines were used to estimate differences in serum N-terminal pro B-type natriuretic peptide (NT-proBNP) levels according to, ethnicity, and ancestry. Ancestry was determined using genetic ancestry informative markers. NT-proBNP concentrations differed significantly by race and ethnicity (black, median 43 pg/ml [interquartile range 17 to 94], Chinese 43 [17 to 90], Hispanic 53 [23 to 107], white 68 [34 to 136]; p = 0.0001). In multivariable models, NT-proBNP was 44{\%} lower (95{\%} confidence interval -48 to -40) in black and 46{\%} lower (-50 to -41) in Chinese, compared with white individuals. Hispanic individuals had intermediate concentrations. Self-identified blacks and Hispanics were the most genetically admixed. Among self-identified black individuals, a 20{\%} increase in genetic European ancestry was associated with 12{\%} higher (1{\%} to 23{\%}) NT-proBNP. Among Hispanic individuals, genetic European and African ancestry were positively and negatively associated with NT-proBNP levels, respectively. In conclusion, NT-proBNP levels differ according to race and ethnicity, with the lowest concentrations in black and Chinese individuals. Racial and ethnic differences in NT-proBNP may have a genetic basis, with European and African ancestry associated with higher and lower NT-proBNP concentrations, respectively.",
author = "Gupta, {Deepak K.} and Daniels, {Lori B.} and Susan Cheng and deFilippi, {Christopher R.} and Criqui, {Michael H.} and Maisel, {Alan S.} and Lima, {Joao A.} and Hossein Bahrami and Philip Greenland and Mary Cushman and Russell Tracy and David Siscovick and Bertoni, {Alain G.} and Valentina Cannone and Burnett, {John C Jr.} and Carr, {John Jeffrey} and Wang, {Thomas J.}",
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AU - Gupta, Deepak K.

AU - Daniels, Lori B.

AU - Cheng, Susan

AU - deFilippi, Christopher R.

AU - Criqui, Michael H.

AU - Maisel, Alan S.

AU - Lima, Joao A.

AU - Bahrami, Hossein

AU - Greenland, Philip

AU - Cushman, Mary

AU - Tracy, Russell

AU - Siscovick, David

AU - Bertoni, Alain G.

AU - Cannone, Valentina

AU - Burnett, John C Jr.

AU - Carr, John Jeffrey

AU - Wang, Thomas J.

PY - 2017

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