Differences in Duration and Degree of Cytomegalovirus DNAemia Observed with Two Standardized Quantitative Nucleic Acid Tests and Implications for Clinical Care

Atibordee Meesing, Jeffrey J. Germer, Joseph D. Yao, Michelle L. Gartner, Benjamin J. Digmann, Raymund R. Razonable

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Cytomegalovirus (CMV) viral loads overall were 0.29 log IU/mL higher with cobas CMV for use on the cobas 6800/8800 System (cobas CMV) compared with Cobas AmpliPrep/Cobas TaqMan CMV Test (CAP/CTM CMV). Cytomegalovirus DNAemia was detected 11.5 days earlier by cobas CMV, whereas clearance was delayed by 12.8 days. Cytomegalovirus remained detectable by cobas CMV in 44.2% of patients at the time of viral clearance as determined by CAP/CTM CMV. Undetectable viral load by cobas CMV at end of treatment was associated with reduced risk for retreatment (odds ratio, 0.26; 95% confidence interval, 0.04-0.99; P =. 05). The use of different quantitative cytomegalovirus nucleic acid tests may affect direct patient care as a result of significant differences in reporting the degree of CMV DNAemia and the time to first detection and clearance of CMV DNAemia.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalJournal of Nutrition
Volume149
DOIs
StatePublished - Dec 1 2019

Keywords

  • cytomegalovirus
  • infection
  • nucleic acid testing
  • transplantation
  • viral load

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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