Differences in apical and non-Apical types of hypertrophic cardiomyopathy: A prospective analysis of clinical, echocardiographic, and cardiac magnetic resonance findings and outcome from 350 patients

Eun Kyoung Kim, Sang Chol Lee, Ji Won Hwang, Sung A. Chang, Sung Ji Park, Young Keun On, Kyoung Min Park, Yeon Hyeon Choe, Sung Mok Kim, Seung Woo Park, Jae Kuen Oh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aims Apical hypertrophic cardiomyopathy (ApHCM) is thought to have a favourable clinical outcome, compared with other types of HCM. We sought to investigate the clinical and anatomical differences in cardiovascular imaging between ApHCM and non-ApHCM. Methods and results A total of 350 patients diagnosed with HCM underwent cardiovascular magnetic resonance (CMR) and echocardiography. All enrolled subjects were prospectively followed up for adverse clinical outcomes. Eighty-five patients were classified as ApHCM. On CMR, the amount and proportion of late gadolinium enhancement (LGE) as well as left ventricular volumetric parameters were evaluated. Echocardiographic evaluations included diastolic function and global strain. Patients with ApHCM were less likely to present with history of syncope and have less frequency of family history of sudden cardiac death than those with non-ApHCM. Functional class was also more favourable in ApHCM [frequency of New York Heart Association (NYHA) class I; 89.4 vs. 66.8%, P < 0.001]. LGE was less frequently detected (87.1 vs. 93.9%, P = 0.04), and the amount of LGE was significantly smaller in ApHCM (7.0±6.0 vs. 14.6±10.5%, P < 0.001). The E/e' level and left atrial volume index were also lower in ApHCM patients (all P < 0.001). During follow-up, a composite of adverse clinical events including cardiac death, admission for heart failure, and cerebrovascular accident was higher in patients with ApHCM than those with non-ApHCM (P = 0.01). Conclusion ApHCM showed a relatively small burden of myocardial fibrosis and less severe diastolic dysfunction and subsequently more favourable clinical manifestations in comparison with other HCMs. This may be one explanation of why most patients with ApHCM show a benign course of disease compared with non-ApHCM.

Original languageEnglish (US)
Pages (from-to)678-686
Number of pages9
JournalEuropean Heart Journal Cardiovascular Imaging
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2016

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Hypertrophic Cardiomyopathy
Magnetic Resonance Spectroscopy
Gadolinium
Sudden Cardiac Death
Syncope
Echocardiography
Fibrosis

Keywords

  • Apical hypertrophy
  • Cardiac magnetic resonance imaging
  • Hypertrophic cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Differences in apical and non-Apical types of hypertrophic cardiomyopathy : A prospective analysis of clinical, echocardiographic, and cardiac magnetic resonance findings and outcome from 350 patients. / Kim, Eun Kyoung; Lee, Sang Chol; Hwang, Ji Won; Chang, Sung A.; Park, Sung Ji; On, Young Keun; Park, Kyoung Min; Choe, Yeon Hyeon; Kim, Sung Mok; Park, Seung Woo; Oh, Jae Kuen.

In: European Heart Journal Cardiovascular Imaging, Vol. 17, No. 6, 01.06.2016, p. 678-686.

Research output: Contribution to journalArticle

Kim, Eun Kyoung ; Lee, Sang Chol ; Hwang, Ji Won ; Chang, Sung A. ; Park, Sung Ji ; On, Young Keun ; Park, Kyoung Min ; Choe, Yeon Hyeon ; Kim, Sung Mok ; Park, Seung Woo ; Oh, Jae Kuen. / Differences in apical and non-Apical types of hypertrophic cardiomyopathy : A prospective analysis of clinical, echocardiographic, and cardiac magnetic resonance findings and outcome from 350 patients. In: European Heart Journal Cardiovascular Imaging. 2016 ; Vol. 17, No. 6. pp. 678-686.
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abstract = "Aims Apical hypertrophic cardiomyopathy (ApHCM) is thought to have a favourable clinical outcome, compared with other types of HCM. We sought to investigate the clinical and anatomical differences in cardiovascular imaging between ApHCM and non-ApHCM. Methods and results A total of 350 patients diagnosed with HCM underwent cardiovascular magnetic resonance (CMR) and echocardiography. All enrolled subjects were prospectively followed up for adverse clinical outcomes. Eighty-five patients were classified as ApHCM. On CMR, the amount and proportion of late gadolinium enhancement (LGE) as well as left ventricular volumetric parameters were evaluated. Echocardiographic evaluations included diastolic function and global strain. Patients with ApHCM were less likely to present with history of syncope and have less frequency of family history of sudden cardiac death than those with non-ApHCM. Functional class was also more favourable in ApHCM [frequency of New York Heart Association (NYHA) class I; 89.4 vs. 66.8{\%}, P < 0.001]. LGE was less frequently detected (87.1 vs. 93.9{\%}, P = 0.04), and the amount of LGE was significantly smaller in ApHCM (7.0±6.0 vs. 14.6±10.5{\%}, P < 0.001). The E/e' level and left atrial volume index were also lower in ApHCM patients (all P < 0.001). During follow-up, a composite of adverse clinical events including cardiac death, admission for heart failure, and cerebrovascular accident was higher in patients with ApHCM than those with non-ApHCM (P = 0.01). Conclusion ApHCM showed a relatively small burden of myocardial fibrosis and less severe diastolic dysfunction and subsequently more favourable clinical manifestations in comparison with other HCMs. This may be one explanation of why most patients with ApHCM show a benign course of disease compared with non-ApHCM.",
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T1 - Differences in apical and non-Apical types of hypertrophic cardiomyopathy

T2 - A prospective analysis of clinical, echocardiographic, and cardiac magnetic resonance findings and outcome from 350 patients

AU - Kim, Eun Kyoung

AU - Lee, Sang Chol

AU - Hwang, Ji Won

AU - Chang, Sung A.

AU - Park, Sung Ji

AU - On, Young Keun

AU - Park, Kyoung Min

AU - Choe, Yeon Hyeon

AU - Kim, Sung Mok

AU - Park, Seung Woo

AU - Oh, Jae Kuen

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Aims Apical hypertrophic cardiomyopathy (ApHCM) is thought to have a favourable clinical outcome, compared with other types of HCM. We sought to investigate the clinical and anatomical differences in cardiovascular imaging between ApHCM and non-ApHCM. Methods and results A total of 350 patients diagnosed with HCM underwent cardiovascular magnetic resonance (CMR) and echocardiography. All enrolled subjects were prospectively followed up for adverse clinical outcomes. Eighty-five patients were classified as ApHCM. On CMR, the amount and proportion of late gadolinium enhancement (LGE) as well as left ventricular volumetric parameters were evaluated. Echocardiographic evaluations included diastolic function and global strain. Patients with ApHCM were less likely to present with history of syncope and have less frequency of family history of sudden cardiac death than those with non-ApHCM. Functional class was also more favourable in ApHCM [frequency of New York Heart Association (NYHA) class I; 89.4 vs. 66.8%, P < 0.001]. LGE was less frequently detected (87.1 vs. 93.9%, P = 0.04), and the amount of LGE was significantly smaller in ApHCM (7.0±6.0 vs. 14.6±10.5%, P < 0.001). The E/e' level and left atrial volume index were also lower in ApHCM patients (all P < 0.001). During follow-up, a composite of adverse clinical events including cardiac death, admission for heart failure, and cerebrovascular accident was higher in patients with ApHCM than those with non-ApHCM (P = 0.01). Conclusion ApHCM showed a relatively small burden of myocardial fibrosis and less severe diastolic dysfunction and subsequently more favourable clinical manifestations in comparison with other HCMs. This may be one explanation of why most patients with ApHCM show a benign course of disease compared with non-ApHCM.

AB - Aims Apical hypertrophic cardiomyopathy (ApHCM) is thought to have a favourable clinical outcome, compared with other types of HCM. We sought to investigate the clinical and anatomical differences in cardiovascular imaging between ApHCM and non-ApHCM. Methods and results A total of 350 patients diagnosed with HCM underwent cardiovascular magnetic resonance (CMR) and echocardiography. All enrolled subjects were prospectively followed up for adverse clinical outcomes. Eighty-five patients were classified as ApHCM. On CMR, the amount and proportion of late gadolinium enhancement (LGE) as well as left ventricular volumetric parameters were evaluated. Echocardiographic evaluations included diastolic function and global strain. Patients with ApHCM were less likely to present with history of syncope and have less frequency of family history of sudden cardiac death than those with non-ApHCM. Functional class was also more favourable in ApHCM [frequency of New York Heart Association (NYHA) class I; 89.4 vs. 66.8%, P < 0.001]. LGE was less frequently detected (87.1 vs. 93.9%, P = 0.04), and the amount of LGE was significantly smaller in ApHCM (7.0±6.0 vs. 14.6±10.5%, P < 0.001). The E/e' level and left atrial volume index were also lower in ApHCM patients (all P < 0.001). During follow-up, a composite of adverse clinical events including cardiac death, admission for heart failure, and cerebrovascular accident was higher in patients with ApHCM than those with non-ApHCM (P = 0.01). Conclusion ApHCM showed a relatively small burden of myocardial fibrosis and less severe diastolic dysfunction and subsequently more favourable clinical manifestations in comparison with other HCMs. This may be one explanation of why most patients with ApHCM show a benign course of disease compared with non-ApHCM.

KW - Apical hypertrophy

KW - Cardiac magnetic resonance imaging

KW - Hypertrophic cardiomyopathy

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