Dietary flavonoid intake and non-Hodgkin lymphoma risk

Cara L. Frankenfeld, James R Cerhan, Wendy Cozen, Scott Davis, Maryjean Schenk, Lindsay M. Morton, Patricia Hartge, Mary H. Ward

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: The role of dietary factors in non-Hodgkin lymphoma (NHL) risk is not yet well understood. Dietary flavonoids are polyphenolic compounds proposed to be anticarcinogenic. Flavonoids are well-characterized antioxidants and metal chelators, and certain flavonoids exhibit antiproliferative and antiestrogenic effects. Objective: We aimed to evaluate the hypothesis that higher flavonoid intake is associated with lower NHL risk. Design: During 1998-2000, we identified incident NHL cases aged 20-74 y from 4 US Surveillance, Epidemiology, and End Results cancer registries. Controls without history of NHL were selected by random-digit dialing or from Medicare files and frequency-matched to cases by age, center, race, and sex. Using 3 recently developed US Department of Agriculture nutrient-specific databases, flavonoid intake was estimated from participant responses to a 117-item food-frequency questionnaire (n = 466 cases and 390 controls). NHL risk in relation to flavonoid intake in quartiles was evaluated after adjustment for age, sex, registry, education, NHL family history, and energy intake. Results: Higher total flavonoid intake was significantly associated with lower risk of NHL (P for trend < 0.01): a 47% lower risk in the highest quartile of intake than in the lowest (95% CI: 31%, 73%). Higher intakes of flavonols, epicatechins, anthocyanidins, and proanthocyanidins were each significantly associated with decreased NHL risk. Similar patterns of risk were observed for the major NHL subtypes - diffuse large B-cell lymphoma (n = 167) and follicular lymphoma (n = 146). Conclusion: A higher intake of flavonoids, dietary components with several putative anticarcinogenic activities, may be associated with lower NHL risk.

Original languageEnglish (US)
Pages (from-to)1439-1445
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number5
StatePublished - May 1 2008

Fingerprint

non-Hodgkin lymphoma
Flavonoids
Non-Hodgkin's Lymphoma
flavonoids
lymphoma
Registries
Food
United States Department of Agriculture
Proanthocyanidins
Flavonols
anthocyanidins
Follicular Lymphoma
Sex Education
Anthocyanins
Lymphoma, Large B-Cell, Diffuse
Catechin
gender
food frequency questionnaires
epicatechin
anticarcinogenic activity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Frankenfeld, C. L., Cerhan, J. R., Cozen, W., Davis, S., Schenk, M., Morton, L. M., ... Ward, M. H. (2008). Dietary flavonoid intake and non-Hodgkin lymphoma risk. American Journal of Clinical Nutrition, 87(5), 1439-1445.

Dietary flavonoid intake and non-Hodgkin lymphoma risk. / Frankenfeld, Cara L.; Cerhan, James R; Cozen, Wendy; Davis, Scott; Schenk, Maryjean; Morton, Lindsay M.; Hartge, Patricia; Ward, Mary H.

In: American Journal of Clinical Nutrition, Vol. 87, No. 5, 01.05.2008, p. 1439-1445.

Research output: Contribution to journalArticle

Frankenfeld, CL, Cerhan, JR, Cozen, W, Davis, S, Schenk, M, Morton, LM, Hartge, P & Ward, MH 2008, 'Dietary flavonoid intake and non-Hodgkin lymphoma risk', American Journal of Clinical Nutrition, vol. 87, no. 5, pp. 1439-1445.
Frankenfeld CL, Cerhan JR, Cozen W, Davis S, Schenk M, Morton LM et al. Dietary flavonoid intake and non-Hodgkin lymphoma risk. American Journal of Clinical Nutrition. 2008 May 1;87(5):1439-1445.
Frankenfeld, Cara L. ; Cerhan, James R ; Cozen, Wendy ; Davis, Scott ; Schenk, Maryjean ; Morton, Lindsay M. ; Hartge, Patricia ; Ward, Mary H. / Dietary flavonoid intake and non-Hodgkin lymphoma risk. In: American Journal of Clinical Nutrition. 2008 ; Vol. 87, No. 5. pp. 1439-1445.
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