TY - JOUR
T1 - Dietary calcium intake and rates of bone loss in women
AU - Riggs, B. L.
AU - Wahner, H. W.
AU - Melton, L. J.
AU - Richelson, L. S.
AU - Judd, H. L.
AU - O'Fallon, W. M.
PY - 1987
Y1 - 1987
N2 - We measured bone mineral density (BMD) at the midradius and lumbar spine in 106 normal women, ages 23-84 yr (61 were postmenopausal). Three to nine measurements (median, four) were made over 2.6 to 6.6 yr (mean, 4.1 yr). The correlation between calcium intake (range, 260-2,035 mg/de) and rate of change in BMD was not significant at the midradius (r = 0.06) or lumbar spine (r = 0.08), even after adjusting for age, menopausal status, and serum estrogen levels by multiple regression analysis. Women in the lower (mean, 501 mg/d) and in the upper (mean, 1,397 mg/d) quartiles of dietary intake had similar rates of change in BMD (%/yr [mean±SE], at midradius, -0.78±0.24 and -0.91±0.17 for lower and upper quartiles, respectively; at lumbar spine, -1.06±0.24 and -0.98±0.24). These data do not support the hypothesis that insufficient dietary calcium is a major cause of bone loss in women.
AB - We measured bone mineral density (BMD) at the midradius and lumbar spine in 106 normal women, ages 23-84 yr (61 were postmenopausal). Three to nine measurements (median, four) were made over 2.6 to 6.6 yr (mean, 4.1 yr). The correlation between calcium intake (range, 260-2,035 mg/de) and rate of change in BMD was not significant at the midradius (r = 0.06) or lumbar spine (r = 0.08), even after adjusting for age, menopausal status, and serum estrogen levels by multiple regression analysis. Women in the lower (mean, 501 mg/d) and in the upper (mean, 1,397 mg/d) quartiles of dietary intake had similar rates of change in BMD (%/yr [mean±SE], at midradius, -0.78±0.24 and -0.91±0.17 for lower and upper quartiles, respectively; at lumbar spine, -1.06±0.24 and -0.98±0.24). These data do not support the hypothesis that insufficient dietary calcium is a major cause of bone loss in women.
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U2 - 10.1172/JCI113191
DO - 10.1172/JCI113191
M3 - Article
C2 - 3654981
AN - SCOPUS:0023572108
SN - 0021-9738
VL - 80
SP - 979
EP - 982
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 4
ER -