Diet-induced obesity and mammary tumor development in relation to estrogen receptor status

Amitabha Ray; Katai J. Nkhata; Joseph P. Grande; Margot P. Cleary

doi:10.1016/j.canlet.2007.02.005

Diet-induced obesity and mammary tumor development in relation to estrogen receptor status

Amitabha Ray, Katai J. Nkhata, Joseph P. Grande, Margot P. Cleary

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Leptin enhances proliferation of estrogen receptor (ER)-positive breast cancer cells in vitro. Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. Neither body weight, diet or serum leptin levels impacted MT latency, burden or tumor grade. However, protein expression in mammary fat pads exhibited elevated PCNA and Cyclin D1 while in MTs, Ob-Rb, IGF-IR, Bcl-2, and Bax were lower in Low-Fat versus High-Fat mice. In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism.

Original language	English (US)
Pages (from-to)	291-300
Number of pages	10
Journal	Cancer Letters
Volume	253
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2007.02.005
State	Published - Aug 18 2007

Keywords

Breast
Cancer
Diet-induced obesity
Estrogen receptor
High-Fat diet
IGF-I
Leptin
Tumors

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2007.02.005

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title = "Diet-induced obesity and mammary tumor development in relation to estrogen receptor status",

abstract = "Leptin enhances proliferation of estrogen receptor (ER)-positive breast cancer cells in vitro. Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. Neither body weight, diet or serum leptin levels impacted MT latency, burden or tumor grade. However, protein expression in mammary fat pads exhibited elevated PCNA and Cyclin D1 while in MTs, Ob-Rb, IGF-IR, Bcl-2, and Bax were lower in Low-Fat versus High-Fat mice. In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism.",

keywords = "Breast, Cancer, Diet-induced obesity, Estrogen receptor, High-Fat diet, IGF-I, Leptin, Tumors",

author = "Amitabha Ray and Nkhata, {Katai J.} and Grande, {Joseph P.} and Cleary, {Margot P.}",

note = "Funding Information: We thank Amy Snider and Michelle Jacobson for help caring for the mice. Drs. A. Ray and K. Nkhata contributed equally to this study. This research was supported by the Breast Cancer Research Foundation with additional support from The Hormel Foundation.",

year = "2007",

month = aug,

day = "18",

doi = "10.1016/j.canlet.2007.02.005",

language = "English (US)",

volume = "253",

pages = "291--300",

journal = "Cancer Letters",

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TY - JOUR

T1 - Diet-induced obesity and mammary tumor development in relation to estrogen receptor status

AU - Ray, Amitabha

AU - Nkhata, Katai J.

AU - Grande, Joseph P.

AU - Cleary, Margot P.

N1 - Funding Information: We thank Amy Snider and Michelle Jacobson for help caring for the mice. Drs. A. Ray and K. Nkhata contributed equally to this study. This research was supported by the Breast Cancer Research Foundation with additional support from The Hormel Foundation.

PY - 2007/8/18

Y1 - 2007/8/18

N2 - Leptin enhances proliferation of estrogen receptor (ER)-positive breast cancer cells in vitro. Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. Neither body weight, diet or serum leptin levels impacted MT latency, burden or tumor grade. However, protein expression in mammary fat pads exhibited elevated PCNA and Cyclin D1 while in MTs, Ob-Rb, IGF-IR, Bcl-2, and Bax were lower in Low-Fat versus High-Fat mice. In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism.

AB - Leptin enhances proliferation of estrogen receptor (ER)-positive breast cancer cells in vitro. Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. Neither body weight, diet or serum leptin levels impacted MT latency, burden or tumor grade. However, protein expression in mammary fat pads exhibited elevated PCNA and Cyclin D1 while in MTs, Ob-Rb, IGF-IR, Bcl-2, and Bax were lower in Low-Fat versus High-Fat mice. In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism.

KW - Breast

KW - Cancer

KW - Diet-induced obesity

KW - Estrogen receptor

KW - High-Fat diet

KW - IGF-I

KW - Leptin

KW - Tumors

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JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Diet-induced obesity and mammary tumor development in relation to estrogen receptor status

Abstract

Keywords

ASJC Scopus subject areas

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