Diet effects on fatty acid metabolism in lean and obese humans

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The primary role of adipose tissue is to serve as a temporary storage site for energy in the form of nonesterified fatty acids. The regulation of adipose tissue lipolysis, which allows the appropriate delivery of fatty acids to meet the lipid fuel needs of lean tissue, is affected by the amount and the location of fat, as well as by the diet. Excessive accumulation of triacylglycerol fatty acids (obesity) is associated with an increased risk of insulin resistance, diabetes, hyperlipidemia, and hypertension. Some of these abnormalities may be related to dysregulation of fatty acid metabolism. Body fat distribution exerts a major influence on endogenous nonesterified fatty acid metabolism, which may in turn mediate some of the metabolic abnormalities associated with upper-body obesity. The effects of diet on fatty acid metabolism can be dramatic and are not the same in upper-body and lower-body obesity. Different obesity phenotypes may respond differently to low-fat, high-complex-carbohydrate diets, and the response is further modified depending on whether the diet is isoenergetic or restricted in energy.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Volume67
Issue number3 SUPPL.
StatePublished - 1998

Fingerprint

fatty acid metabolism
obesity
Fatty Acids
Obesity
Diet
Nonesterified Fatty Acids
diet
adipose tissue
free fatty acids
Adipose Tissue
lipids
Fats
fatty acids
Body Fat Distribution
body fat distribution
Lipolysis
energy
lipolysis
hyperlipidemia
Hyperlipidemias

Keywords

  • Adipose tissue
  • Body fat distribution
  • Diet composition
  • Humans
  • Insulin
  • Nonesterified fatty acids
  • Obesity
  • Triacylglycerol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Diet effects on fatty acid metabolism in lean and obese humans. / Jensen, Michael Dennis.

In: American Journal of Clinical Nutrition, Vol. 67, No. 3 SUPPL., 1998.

Research output: Contribution to journalArticle

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