Abstract
Objective. - To test whether high dietary intakes of fat, protein, and milk are associated with the development of non-Hodgkin lymphoma in older women. Design. - Prospective cohort study with a 7-year follow-up period. Setting. - General community. Participants. - Sample of 35 156 Iowa women aged 55 to 69 years with no prior history of cancer who returned the 1986 baseline questionnaire. Main Outcome Measure. - Non-Hodgkin lymphoma (104 incident cases). Main Results. - After controlling for age, marital status, residence, total energy intake, and transfusion history, the relative risks (RRs) for the highest tertile of intake compared with the lowest were 2.00 (95% confidence interval [CI], 1.21-3.30; P for trend=.01) for animal fat, 1.69 (95% CI, 1.07-2.67; P for trend=.02) for saturated fat, and 1.90 (95% CI, 1.18-3.04; P for trend=.01) for monounsaturated fat, and there was no association with vegetable fat or polyunsaturated fat. Greater intake of animal protein (RR=1.52; 95% CI, 0.94-2.44; P for trend=.08), but not vegetable protein, was associated with elevated risk, and this was mainly explained by greater consumption of red meat (RR=1.98; 95% CI, 1.13-3.47; P for trend=.02) and hamburger in particular (RR=2.35; 95% CI, 1.23-4.48; P for trend=.02). Milk and dairy product consumption were not associated with elevated risk. There was also a decreased risk of non-Hodgkin lymphoma with greater consumption of fruits (RR=0.64; 95% CI, 0.40-1.05; P for trend=.07). Conclusions. - A high-meat diet and a high intake of fat from animal sources is associated with an increased risk of non-Hodgkin lymphoma in older women.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1315-1321 |
| Number of pages | 7 |
| Journal | Journal of the American Medical Association |
| Volume | 275 |
| Issue number | 17 |
| DOIs | |
| State | Published - May 1 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Diet and risk of non-Hodgkin lymphoma in older women. / Chiu, Brian C H; Cerhan, James R; Folsom, Aaron R.; Sellers, Thomas A.; Kushi, Lawrence H.; Wallace, Robert B.; Zheng, Wei; Potter, John D.
In: Journal of the American Medical Association, Vol. 275, No. 17, 01.05.1996, p. 1315-1321.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diet and risk of non-Hodgkin lymphoma in older women
AU - Chiu, Brian C H
AU - Cerhan, James R
AU - Folsom, Aaron R.
AU - Sellers, Thomas A.
AU - Kushi, Lawrence H.
AU - Wallace, Robert B.
AU - Zheng, Wei
AU - Potter, John D.
PY - 1996/5/1
Y1 - 1996/5/1
N2 - Objective. - To test whether high dietary intakes of fat, protein, and milk are associated with the development of non-Hodgkin lymphoma in older women. Design. - Prospective cohort study with a 7-year follow-up period. Setting. - General community. Participants. - Sample of 35 156 Iowa women aged 55 to 69 years with no prior history of cancer who returned the 1986 baseline questionnaire. Main Outcome Measure. - Non-Hodgkin lymphoma (104 incident cases). Main Results. - After controlling for age, marital status, residence, total energy intake, and transfusion history, the relative risks (RRs) for the highest tertile of intake compared with the lowest were 2.00 (95% confidence interval [CI], 1.21-3.30; P for trend=.01) for animal fat, 1.69 (95% CI, 1.07-2.67; P for trend=.02) for saturated fat, and 1.90 (95% CI, 1.18-3.04; P for trend=.01) for monounsaturated fat, and there was no association with vegetable fat or polyunsaturated fat. Greater intake of animal protein (RR=1.52; 95% CI, 0.94-2.44; P for trend=.08), but not vegetable protein, was associated with elevated risk, and this was mainly explained by greater consumption of red meat (RR=1.98; 95% CI, 1.13-3.47; P for trend=.02) and hamburger in particular (RR=2.35; 95% CI, 1.23-4.48; P for trend=.02). Milk and dairy product consumption were not associated with elevated risk. There was also a decreased risk of non-Hodgkin lymphoma with greater consumption of fruits (RR=0.64; 95% CI, 0.40-1.05; P for trend=.07). Conclusions. - A high-meat diet and a high intake of fat from animal sources is associated with an increased risk of non-Hodgkin lymphoma in older women.
AB - Objective. - To test whether high dietary intakes of fat, protein, and milk are associated with the development of non-Hodgkin lymphoma in older women. Design. - Prospective cohort study with a 7-year follow-up period. Setting. - General community. Participants. - Sample of 35 156 Iowa women aged 55 to 69 years with no prior history of cancer who returned the 1986 baseline questionnaire. Main Outcome Measure. - Non-Hodgkin lymphoma (104 incident cases). Main Results. - After controlling for age, marital status, residence, total energy intake, and transfusion history, the relative risks (RRs) for the highest tertile of intake compared with the lowest were 2.00 (95% confidence interval [CI], 1.21-3.30; P for trend=.01) for animal fat, 1.69 (95% CI, 1.07-2.67; P for trend=.02) for saturated fat, and 1.90 (95% CI, 1.18-3.04; P for trend=.01) for monounsaturated fat, and there was no association with vegetable fat or polyunsaturated fat. Greater intake of animal protein (RR=1.52; 95% CI, 0.94-2.44; P for trend=.08), but not vegetable protein, was associated with elevated risk, and this was mainly explained by greater consumption of red meat (RR=1.98; 95% CI, 1.13-3.47; P for trend=.02) and hamburger in particular (RR=2.35; 95% CI, 1.23-4.48; P for trend=.02). Milk and dairy product consumption were not associated with elevated risk. There was also a decreased risk of non-Hodgkin lymphoma with greater consumption of fruits (RR=0.64; 95% CI, 0.40-1.05; P for trend=.07). Conclusions. - A high-meat diet and a high intake of fat from animal sources is associated with an increased risk of non-Hodgkin lymphoma in older women.
UR - http://www.scopus.com/inward/record.url?scp=0029996509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029996509&partnerID=8YFLogxK
U2 - 10.1001/jama.275.17.1315
DO - 10.1001/jama.275.17.1315
M3 - Article
C2 - 8614116
AN - SCOPUS:0029996509
VL - 275
SP - 1315
EP - 1321
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 17
ER -