Diet and risk of non-Hodgkin lymphoma in older women

Brian C H Chiu, James R Cerhan, Aaron R. Folsom, Thomas A. Sellers, Lawrence H. Kushi, Robert B. Wallace, Wei Zheng, John D. Potter

Research output: Contribution to journalArticle

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Abstract

Objective. - To test whether high dietary intakes of fat, protein, and milk are associated with the development of non-Hodgkin lymphoma in older women. Design. - Prospective cohort study with a 7-year follow-up period. Setting. - General community. Participants. - Sample of 35 156 Iowa women aged 55 to 69 years with no prior history of cancer who returned the 1986 baseline questionnaire. Main Outcome Measure. - Non-Hodgkin lymphoma (104 incident cases). Main Results. - After controlling for age, marital status, residence, total energy intake, and transfusion history, the relative risks (RRs) for the highest tertile of intake compared with the lowest were 2.00 (95% confidence interval [CI], 1.21-3.30; P for trend=.01) for animal fat, 1.69 (95% CI, 1.07-2.67; P for trend=.02) for saturated fat, and 1.90 (95% CI, 1.18-3.04; P for trend=.01) for monounsaturated fat, and there was no association with vegetable fat or polyunsaturated fat. Greater intake of animal protein (RR=1.52; 95% CI, 0.94-2.44; P for trend=.08), but not vegetable protein, was associated with elevated risk, and this was mainly explained by greater consumption of red meat (RR=1.98; 95% CI, 1.13-3.47; P for trend=.02) and hamburger in particular (RR=2.35; 95% CI, 1.23-4.48; P for trend=.02). Milk and dairy product consumption were not associated with elevated risk. There was also a decreased risk of non-Hodgkin lymphoma with greater consumption of fruits (RR=0.64; 95% CI, 0.40-1.05; P for trend=.07). Conclusions. - A high-meat diet and a high intake of fat from animal sources is associated with an increased risk of non-Hodgkin lymphoma in older women.

Original languageEnglish (US)
Pages (from-to)1315-1321
Number of pages7
JournalJournal of the American Medical Association
Volume275
Issue number17
DOIs
StatePublished - May 1 1996
Externally publishedYes

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Non-Hodgkin's Lymphoma
Diet
Confidence Intervals
Fats
Vegetable Proteins
Dairy Products
Milk Proteins
Dietary Fats
Marital Status
Energy Intake
Vegetables
Meat
Fruit
Milk
Cohort Studies
History
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chiu, B. C. H., Cerhan, J. R., Folsom, A. R., Sellers, T. A., Kushi, L. H., Wallace, R. B., ... Potter, J. D. (1996). Diet and risk of non-Hodgkin lymphoma in older women. Journal of the American Medical Association, 275(17), 1315-1321. https://doi.org/10.1001/jama.275.17.1315

Diet and risk of non-Hodgkin lymphoma in older women. / Chiu, Brian C H; Cerhan, James R; Folsom, Aaron R.; Sellers, Thomas A.; Kushi, Lawrence H.; Wallace, Robert B.; Zheng, Wei; Potter, John D.

In: Journal of the American Medical Association, Vol. 275, No. 17, 01.05.1996, p. 1315-1321.

Research output: Contribution to journalArticle

Chiu, BCH, Cerhan, JR, Folsom, AR, Sellers, TA, Kushi, LH, Wallace, RB, Zheng, W & Potter, JD 1996, 'Diet and risk of non-Hodgkin lymphoma in older women', Journal of the American Medical Association, vol. 275, no. 17, pp. 1315-1321. https://doi.org/10.1001/jama.275.17.1315
Chiu, Brian C H ; Cerhan, James R ; Folsom, Aaron R. ; Sellers, Thomas A. ; Kushi, Lawrence H. ; Wallace, Robert B. ; Zheng, Wei ; Potter, John D. / Diet and risk of non-Hodgkin lymphoma in older women. In: Journal of the American Medical Association. 1996 ; Vol. 275, No. 17. pp. 1315-1321.
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abstract = "Objective. - To test whether high dietary intakes of fat, protein, and milk are associated with the development of non-Hodgkin lymphoma in older women. Design. - Prospective cohort study with a 7-year follow-up period. Setting. - General community. Participants. - Sample of 35 156 Iowa women aged 55 to 69 years with no prior history of cancer who returned the 1986 baseline questionnaire. Main Outcome Measure. - Non-Hodgkin lymphoma (104 incident cases). Main Results. - After controlling for age, marital status, residence, total energy intake, and transfusion history, the relative risks (RRs) for the highest tertile of intake compared with the lowest were 2.00 (95{\%} confidence interval [CI], 1.21-3.30; P for trend=.01) for animal fat, 1.69 (95{\%} CI, 1.07-2.67; P for trend=.02) for saturated fat, and 1.90 (95{\%} CI, 1.18-3.04; P for trend=.01) for monounsaturated fat, and there was no association with vegetable fat or polyunsaturated fat. Greater intake of animal protein (RR=1.52; 95{\%} CI, 0.94-2.44; P for trend=.08), but not vegetable protein, was associated with elevated risk, and this was mainly explained by greater consumption of red meat (RR=1.98; 95{\%} CI, 1.13-3.47; P for trend=.02) and hamburger in particular (RR=2.35; 95{\%} CI, 1.23-4.48; P for trend=.02). Milk and dairy product consumption were not associated with elevated risk. There was also a decreased risk of non-Hodgkin lymphoma with greater consumption of fruits (RR=0.64; 95{\%} CI, 0.40-1.05; P for trend=.07). Conclusions. - A high-meat diet and a high intake of fat from animal sources is associated with an increased risk of non-Hodgkin lymphoma in older women.",
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AU - Kushi, Lawrence H.

AU - Wallace, Robert B.

AU - Zheng, Wei

AU - Potter, John D.

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