Diastolic dysfunction: Insights into pathophysiology and pharmacotherapy

C. V. Maniu, M. M. Redfield

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


This review focuses on diastolic dysfunction with special emphasis on isolated diastolic dysfunction where impairment in diastolic function occurs in the absence of concomitant reduction in systolic function. The phenomena which influence diastolic function, the clinical spectrum of diastolic dysfunction, the physiological perturbations which may serve as therapeutic targets for pharmacological therapy and recent therapeutic trials are reviewed. Recommendations regarding the therapeutic approach to the patient with diastolic dysfunction are summarised.

Original languageEnglish (US)
Pages (from-to)997-1008
Number of pages12
JournalExpert Opinion on Pharmacotherapy
Issue number6
StatePublished - Aug 27 2001


  • Congestive heart failure
  • Diastole

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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