TY - JOUR
T1 - Diarrhoea due to small bowel diseases
AU - Murray, Joseph A.
AU - Rubio-Tapia, Alberto
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2012/10
Y1 - 2012/10
N2 - Small intestinal diseases are a common, though often overlooked cause of diarrhoeal illness. Fully 1% of the Caucasian population are affected by coeliac disease and a substantial portion of children living in poverty in the developing world are affected by environmental enteropathy. These are but two examples of the many diseases that cause mucosal injury to the primary digestive and absorptive organ in our body. While diarrhoea may be a common, though not universally seen symptom of small bowel mucosal disease, the consequent malabsorption can lead to substantial malnutrition and nutrient deficiencies. The small intestine, unlike the colon, has been relatively inaccessible, and systematic evaluation is often necessary to identify and treat small intestinal mucosal diseases that lead to diarrhoea. Immunodeficiency states, including HIV enteropathy, adult autoimmune enteropathy, drug-associated enteropathy, and tropical sprue continue to occur and require specific therapy. All patients with severe diarrhoea or diarrhoea associated with features suggestive of malabsorption may have a disease of the small intestinal mucosa that requires careful evaluation and targeted management.
AB - Small intestinal diseases are a common, though often overlooked cause of diarrhoeal illness. Fully 1% of the Caucasian population are affected by coeliac disease and a substantial portion of children living in poverty in the developing world are affected by environmental enteropathy. These are but two examples of the many diseases that cause mucosal injury to the primary digestive and absorptive organ in our body. While diarrhoea may be a common, though not universally seen symptom of small bowel mucosal disease, the consequent malabsorption can lead to substantial malnutrition and nutrient deficiencies. The small intestine, unlike the colon, has been relatively inaccessible, and systematic evaluation is often necessary to identify and treat small intestinal mucosal diseases that lead to diarrhoea. Immunodeficiency states, including HIV enteropathy, adult autoimmune enteropathy, drug-associated enteropathy, and tropical sprue continue to occur and require specific therapy. All patients with severe diarrhoea or diarrhoea associated with features suggestive of malabsorption may have a disease of the small intestinal mucosa that requires careful evaluation and targeted management.
KW - Autoimmune enteropathy
KW - Coeliac disease
KW - HIV enteropathy
KW - Malabsorption
KW - Tropical sprue steatorrhoea
UR - http://www.scopus.com/inward/record.url?scp=84873363941&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873363941&partnerID=8YFLogxK
U2 - 10.1016/j.bpg.2012.11.013
DO - 10.1016/j.bpg.2012.11.013
M3 - Review article
C2 - 23384804
AN - SCOPUS:84873363941
VL - 26
SP - 581
EP - 600
JO - Best Practice and Research: Clinical Gastroenterology
JF - Best Practice and Research: Clinical Gastroenterology
SN - 1521-6918
IS - 5
ER -