Diaphragm muscle adaptations in health and disease

Matthew J. Fogarty, Gary C. Sieck

Research output: Contribution to journalReview article

1 Scopus citations


Breathing is achieved without thought despite being controlled by a complex neural network. The diaphragm is the predominant muscle responsible for force/pressure generation during breathing, but it is also involved in other non-ventilatory expulsive behaviors. This review considers alterations in diaphragm muscle fiber types and the neural control of the diaphragm across our lifespan and in various disease conditions.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalDrug Discovery Today: Disease Models
StatePublished - Jun 1 2019


ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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