Diaphragm motor unit recruitment in rats

Carlos Bernardo Mantilla, Yasin B. Seven, Wen Zhi Zhan, Gary C Sieck

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

We hypothesized that considerable force reserve exists for the diaphragm muscle (DIAm) to generate transdiaphragmatic pressures (Pdi) necessary to sustain ventilation. In rats, we measured Pdi and DIAm EMG activity during different ventilatory (eupnea and hypoxia (10% O 2)-hypercapnia (5% CO 2)) and non-ventilatory (airway occlusion and sneezing induced by intranasal capsaicin) behaviors. Compared to maximum Pdi (Pdi max generated by bilateral phrenic nerve stimulation), the Pdi generated during eupnea (21±2%) and hypoxia-hypercapnia (28±4%) were significantly less (p<0.0001) than that generated during airway occlusion (63±4%) and sneezing (94±5%). The Pdi generated during spontaneous sighs was 62±5% of Pdi max. Relative DIAm EMG activity (root mean square [RMS] amplitude) paralleled the changes in Pdi during different ventilatory and non-ventilatory behaviors (r 2=0.78; p<0.0001). These results support our hypothesis of a considerable force reserve for the DIAm to accomplish ventilatory behaviors. A model for DIAm motor unit recruitment predicted that ventilatory behaviors would require activation of only fatigue resistant units.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalRespiratory Physiology and Neurobiology
Volume173
Issue number1
DOIs
StatePublished - Aug 2010

Fingerprint

Neurophysiological Recruitment
Diaphragm
Muscles
Sneezing
Hypercapnia
Phrenic Nerve
Capsaicin
Carbon Monoxide
Fatigue
Ventilation
Pressure

Keywords

  • Motor units
  • Phrenic nerve
  • Recruitment order
  • Respiration

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Diaphragm motor unit recruitment in rats. / Mantilla, Carlos Bernardo; Seven, Yasin B.; Zhan, Wen Zhi; Sieck, Gary C.

In: Respiratory Physiology and Neurobiology, Vol. 173, No. 1, 08.2010, p. 101-106.

Research output: Contribution to journalArticle

Mantilla, Carlos Bernardo ; Seven, Yasin B. ; Zhan, Wen Zhi ; Sieck, Gary C. / Diaphragm motor unit recruitment in rats. In: Respiratory Physiology and Neurobiology. 2010 ; Vol. 173, No. 1. pp. 101-106.
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