Diagnostik und Therapie der Polymyalgia rheumatica

Translated title of the contribution: Diagnostics and treatment of polymyalgia rheumatica

C. Dejaco, Eric Lawrence Matteson, F. Buttgereit

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Polymyalgia rheumatica (PMR) is the most common autoimmune inflammatory disease in older persons with an average age of onset of 73 years. Typical symptoms include acute or subacute bilateral shoulder pain with severe stiffness and often neck and bilateral hip pain. Giant cell arteritis (GCA) occurs in approximately 20 % of cases and up to two thirds of patients with GCA have symptoms of PMR. There are many disease which mimic PMR, elderly onset rheumatoid arthritis is frequently misdiagnosed as PMR. Although there are no specific laboratory tests, C‑reactive protein and erythrocyte sedimentation rates are elevated in over 90 % of patients. The diagnosis may be aided by imaging, especially ultrasonography and magnetic resonance imaging (MRI). Treatment currently consists of glucocorticoids at an initial dose of 12.5–25 mg prednisone equivalent daily. Treatment duration is typically 2‑3 years but may be longer. Under certain conditions low-dose methotrexate can be used as adjuvant therapy.

Original languageGerman
Pages (from-to)687-700
Number of pages14
JournalZeitschrift fur Rheumatologie
Volume75
Issue number7
DOIs
StatePublished - Sep 1 2016

Fingerprint

Polymyalgia Rheumatica
Giant Cell Arteritis
Shoulder Pain
Blood Sedimentation
Therapeutics
Prednisone
Diagnostic Errors
Age of Onset
Methotrexate
Glucocorticoids
Autoimmune Diseases
Hip
Ultrasonography
Rheumatoid Arthritis
Neck
Magnetic Resonance Imaging
Pain
Proteins

Keywords

  • Arthritis
  • Autoimmune diseases
  • Epidemiology
  • Monitoring
  • Treatment

ASJC Scopus subject areas

  • Rheumatology

Cite this

Diagnostik und Therapie der Polymyalgia rheumatica. / Dejaco, C.; Matteson, Eric Lawrence; Buttgereit, F.

In: Zeitschrift fur Rheumatologie, Vol. 75, No. 7, 01.09.2016, p. 687-700.

Research output: Contribution to journalArticle

Dejaco, C. ; Matteson, Eric Lawrence ; Buttgereit, F. / Diagnostik und Therapie der Polymyalgia rheumatica. In: Zeitschrift fur Rheumatologie. 2016 ; Vol. 75, No. 7. pp. 687-700.
@article{db67295115354b8ba291145b3fcf16e8,
title = "Diagnostik und Therapie der Polymyalgia rheumatica",
abstract = "Polymyalgia rheumatica (PMR) is the most common autoimmune inflammatory disease in older persons with an average age of onset of 73 years. Typical symptoms include acute or subacute bilateral shoulder pain with severe stiffness and often neck and bilateral hip pain. Giant cell arteritis (GCA) occurs in approximately 20 {\%} of cases and up to two thirds of patients with GCA have symptoms of PMR. There are many disease which mimic PMR, elderly onset rheumatoid arthritis is frequently misdiagnosed as PMR. Although there are no specific laboratory tests, C‑reactive protein and erythrocyte sedimentation rates are elevated in over 90 {\%} of patients. The diagnosis may be aided by imaging, especially ultrasonography and magnetic resonance imaging (MRI). Treatment currently consists of glucocorticoids at an initial dose of 12.5–25 mg prednisone equivalent daily. Treatment duration is typically 2‑3 years but may be longer. Under certain conditions low-dose methotrexate can be used as adjuvant therapy.",
keywords = "Arthritis, Autoimmune diseases, Epidemiology, Monitoring, Treatment",
author = "C. Dejaco and Matteson, {Eric Lawrence} and F. Buttgereit",
year = "2016",
month = "9",
day = "1",
doi = "10.1007/s00393-016-0105-3",
language = "German",
volume = "75",
pages = "687--700",
journal = "Zeitschrift fur Rheumatologie",
issn = "0340-1855",
publisher = "D. Steinkopff-Verlag",
number = "7",

}

TY - JOUR

T1 - Diagnostik und Therapie der Polymyalgia rheumatica

AU - Dejaco, C.

AU - Matteson, Eric Lawrence

AU - Buttgereit, F.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Polymyalgia rheumatica (PMR) is the most common autoimmune inflammatory disease in older persons with an average age of onset of 73 years. Typical symptoms include acute or subacute bilateral shoulder pain with severe stiffness and often neck and bilateral hip pain. Giant cell arteritis (GCA) occurs in approximately 20 % of cases and up to two thirds of patients with GCA have symptoms of PMR. There are many disease which mimic PMR, elderly onset rheumatoid arthritis is frequently misdiagnosed as PMR. Although there are no specific laboratory tests, C‑reactive protein and erythrocyte sedimentation rates are elevated in over 90 % of patients. The diagnosis may be aided by imaging, especially ultrasonography and magnetic resonance imaging (MRI). Treatment currently consists of glucocorticoids at an initial dose of 12.5–25 mg prednisone equivalent daily. Treatment duration is typically 2‑3 years but may be longer. Under certain conditions low-dose methotrexate can be used as adjuvant therapy.

AB - Polymyalgia rheumatica (PMR) is the most common autoimmune inflammatory disease in older persons with an average age of onset of 73 years. Typical symptoms include acute or subacute bilateral shoulder pain with severe stiffness and often neck and bilateral hip pain. Giant cell arteritis (GCA) occurs in approximately 20 % of cases and up to two thirds of patients with GCA have symptoms of PMR. There are many disease which mimic PMR, elderly onset rheumatoid arthritis is frequently misdiagnosed as PMR. Although there are no specific laboratory tests, C‑reactive protein and erythrocyte sedimentation rates are elevated in over 90 % of patients. The diagnosis may be aided by imaging, especially ultrasonography and magnetic resonance imaging (MRI). Treatment currently consists of glucocorticoids at an initial dose of 12.5–25 mg prednisone equivalent daily. Treatment duration is typically 2‑3 years but may be longer. Under certain conditions low-dose methotrexate can be used as adjuvant therapy.

KW - Arthritis

KW - Autoimmune diseases

KW - Epidemiology

KW - Monitoring

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=84982840433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982840433&partnerID=8YFLogxK

U2 - 10.1007/s00393-016-0105-3

DO - 10.1007/s00393-016-0105-3

M3 - Article

C2 - 27488446

AN - SCOPUS:84982840433

VL - 75

SP - 687

EP - 700

JO - Zeitschrift fur Rheumatologie

JF - Zeitschrift fur Rheumatologie

SN - 0340-1855

IS - 7

ER -