Diagnostic uses of Pax5 immunohistochemistry

Andrew L Feldman, Ahmet Dogan

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Pax5, or B-cell-specific activator protein, is a nuclear protein in the paired-box containing (PAX) family of transcription factors involved in control of organ development and tissue differentiation. Pax5 is mostly expressed in B lymphocytes and B-cell lymphomas, although recent data have shown expression in the developing central nervous system, some neuroendocrine tumors, and occasional myeloid leukemias. Pax5 immunohistochemistry shows robust nuclear staining, and has become a valuable tool in the diagnosis and subclassification of lymphomas. Pax5 staining is positive in most Hodgkin and B-cell non-Hodgkin lymphomas, and also precursor B-cell lymphoblastic neoplasms. Plasma cell neoplasms, multiple myeloma, and plasmablastic lymphomas typically are negative. T-cell lymphomas are, to date, consistently negative. Recently, Pax5 expression has been described in the majority of small cell carcinomas and Merkel cell carcinomas. Rare cases of Pax5 expression in other carcinomas have been reported. With these exceptions, Pax5 immunohistochemistry is fairly specific for B-cell lineage and is a valuable addition to the armamentarium of markers available for lymphoma subtyping.

Original languageEnglish (US)
Pages (from-to)323-334
Number of pages12
JournalAdvances in Anatomic Pathology
Volume14
Issue number5
DOIs
StatePublished - Sep 2007

Fingerprint

B-Cell Lymphoma
PAX5 Transcription Factor
Lymphoma
Plasma Cell Neoplasms
B-Lymphocytes
Immunohistochemistry
Staining and Labeling
Merkel Cell Carcinoma
Myeloid Leukemia
Small Cell Carcinoma
B-Lymphoid Precursor Cells
Neuroendocrine Tumors
T-Cell Lymphoma
Cell Lineage
Nuclear Proteins
Multiple Myeloma
Hodgkin Disease
Non-Hodgkin's Lymphoma
Transcription Factors
Central Nervous System

Keywords

  • B lymphocytes
  • Hodgkin lymphoma
  • Immunohistochemistry
  • Immunophenotyping
  • Merkel cell carcinoma
  • Non-Hodgkin lymphoma
  • Pax5
  • Small cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

Cite this

Diagnostic uses of Pax5 immunohistochemistry. / Feldman, Andrew L; Dogan, Ahmet.

In: Advances in Anatomic Pathology, Vol. 14, No. 5, 09.2007, p. 323-334.

Research output: Contribution to journalArticle

Feldman, Andrew L ; Dogan, Ahmet. / Diagnostic uses of Pax5 immunohistochemistry. In: Advances in Anatomic Pathology. 2007 ; Vol. 14, No. 5. pp. 323-334.
@article{4680c9994477459d8b0eaf23c4c388fb,
title = "Diagnostic uses of Pax5 immunohistochemistry",
abstract = "Pax5, or B-cell-specific activator protein, is a nuclear protein in the paired-box containing (PAX) family of transcription factors involved in control of organ development and tissue differentiation. Pax5 is mostly expressed in B lymphocytes and B-cell lymphomas, although recent data have shown expression in the developing central nervous system, some neuroendocrine tumors, and occasional myeloid leukemias. Pax5 immunohistochemistry shows robust nuclear staining, and has become a valuable tool in the diagnosis and subclassification of lymphomas. Pax5 staining is positive in most Hodgkin and B-cell non-Hodgkin lymphomas, and also precursor B-cell lymphoblastic neoplasms. Plasma cell neoplasms, multiple myeloma, and plasmablastic lymphomas typically are negative. T-cell lymphomas are, to date, consistently negative. Recently, Pax5 expression has been described in the majority of small cell carcinomas and Merkel cell carcinomas. Rare cases of Pax5 expression in other carcinomas have been reported. With these exceptions, Pax5 immunohistochemistry is fairly specific for B-cell lineage and is a valuable addition to the armamentarium of markers available for lymphoma subtyping.",
keywords = "B lymphocytes, Hodgkin lymphoma, Immunohistochemistry, Immunophenotyping, Merkel cell carcinoma, Non-Hodgkin lymphoma, Pax5, Small cell carcinoma",
author = "Feldman, {Andrew L} and Ahmet Dogan",
year = "2007",
month = "9",
doi = "10.1097/PAP.0b013e3180ca8a49",
language = "English (US)",
volume = "14",
pages = "323--334",
journal = "Advances in Anatomic Pathology",
issn = "1072-4109",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Diagnostic uses of Pax5 immunohistochemistry

AU - Feldman, Andrew L

AU - Dogan, Ahmet

PY - 2007/9

Y1 - 2007/9

N2 - Pax5, or B-cell-specific activator protein, is a nuclear protein in the paired-box containing (PAX) family of transcription factors involved in control of organ development and tissue differentiation. Pax5 is mostly expressed in B lymphocytes and B-cell lymphomas, although recent data have shown expression in the developing central nervous system, some neuroendocrine tumors, and occasional myeloid leukemias. Pax5 immunohistochemistry shows robust nuclear staining, and has become a valuable tool in the diagnosis and subclassification of lymphomas. Pax5 staining is positive in most Hodgkin and B-cell non-Hodgkin lymphomas, and also precursor B-cell lymphoblastic neoplasms. Plasma cell neoplasms, multiple myeloma, and plasmablastic lymphomas typically are negative. T-cell lymphomas are, to date, consistently negative. Recently, Pax5 expression has been described in the majority of small cell carcinomas and Merkel cell carcinomas. Rare cases of Pax5 expression in other carcinomas have been reported. With these exceptions, Pax5 immunohistochemistry is fairly specific for B-cell lineage and is a valuable addition to the armamentarium of markers available for lymphoma subtyping.

AB - Pax5, or B-cell-specific activator protein, is a nuclear protein in the paired-box containing (PAX) family of transcription factors involved in control of organ development and tissue differentiation. Pax5 is mostly expressed in B lymphocytes and B-cell lymphomas, although recent data have shown expression in the developing central nervous system, some neuroendocrine tumors, and occasional myeloid leukemias. Pax5 immunohistochemistry shows robust nuclear staining, and has become a valuable tool in the diagnosis and subclassification of lymphomas. Pax5 staining is positive in most Hodgkin and B-cell non-Hodgkin lymphomas, and also precursor B-cell lymphoblastic neoplasms. Plasma cell neoplasms, multiple myeloma, and plasmablastic lymphomas typically are negative. T-cell lymphomas are, to date, consistently negative. Recently, Pax5 expression has been described in the majority of small cell carcinomas and Merkel cell carcinomas. Rare cases of Pax5 expression in other carcinomas have been reported. With these exceptions, Pax5 immunohistochemistry is fairly specific for B-cell lineage and is a valuable addition to the armamentarium of markers available for lymphoma subtyping.

KW - B lymphocytes

KW - Hodgkin lymphoma

KW - Immunohistochemistry

KW - Immunophenotyping

KW - Merkel cell carcinoma

KW - Non-Hodgkin lymphoma

KW - Pax5

KW - Small cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=34548165815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548165815&partnerID=8YFLogxK

U2 - 10.1097/PAP.0b013e3180ca8a49

DO - 10.1097/PAP.0b013e3180ca8a49

M3 - Article

C2 - 17717432

AN - SCOPUS:34548165815

VL - 14

SP - 323

EP - 334

JO - Advances in Anatomic Pathology

JF - Advances in Anatomic Pathology

SN - 1072-4109

IS - 5

ER -