Diagnostic Significance of Detecting Dysgranulopoiesis in Chronic Myeloid Leukemia

Yin Xu, Michelle M. Dolan, Phuong L. Nguyen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We examined whether the detection of dysgranulopoiesis in blood or bone marrow would predict chronic myeloid leukemia (CML) in transformation in 31 cases that fulfilled World Health Organization criteria for disease transformation, including 14 in accelerated phase (AP), 10 in myeloid blast crisis (MBC), and 7 in lymphoid blast crisis (LBC). Dysgranulopoiesis was detected in 7 cases, 6 in AP and 1 in MBC, but not in LBC or chronic phase cases. In 3 AP cases, dysgranulopoiesis was identified 2 to 5 months before the morphologic diagnosis of transformation. Two AP cases showed no dysgranulopoiesis in previous blood or marrow smears. For 2 cases (1 AP and 1 MBC), no previous blood or marrow specimens were available. Cytogenetic information was available for 6 of 7 cases with and 22 of 24 cases without dysgranulopoiesis. All cases with dysgranulopoiesis had secondary chromosome abnormalities in addition to t(9;22). In 5 (83%) of 6 cases with dysgranulopoiesis, the secondary chromosome abnormalities included abnormalities of 17p. In contrast, none of the 22 cases of CML in AP or BC but without dysgranulopoiesis showed 17p abnormalities (P = .001). Our findings demonstrated that dysgranulopoiesis was associated strongly with chromosome 17p abnormalities and may indicate the onset of or impending disease transformation.

Original languageEnglish (US)
Pages (from-to)778-784
Number of pages7
JournalAmerican journal of clinical pathology
Volume120
Issue number5
DOIs
StatePublished - Nov 2003

Keywords

  • Accelerated phase
  • Blast crisis
  • Chromosome 17p
  • Chronic myeloid leukemia
  • Dysgranulopoiesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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