Diagnostic scores predict morbidity and mortality in patients hospitalized for heart failure with preserved ejection fraction

Frederik H. Verbrugge, Yogesh N.V. Reddy, Hidemi Sorimachi, Kazunori Omote, Rickey E. Carter, Barry A. Borlaug

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To investigate the prognostic value of diagnostic scores for heart failure (HF) with preserved ejection fraction (HFpEF). Methods and results: Consecutive patients with HFpEF admitted for unequivocal decompensated HF treated with intravenous loop diuretics were evaluated (n = 443; mean age 78 ± 12 years; 60% women). The HFA-PEFF and H2FPEF scores were calculated for all patients with echocardiography data available within 1 year and the population was stratified according to HFA-PEFF scores 2–4 (n = 79), 5 (n = 93), or 6 (n = 271) and H2FPEF score probabilities <90% (n = 80), 90–95% (n = 61), and 96–100% (n = 293). HF readmission rates (95% confidence intervals) increased from 28.9 (22.7–35.0) per 100 patient-years in HFA-PEFF 2–4 to 46.0 (38.5–53.5) in HFA-PEFF 5 and 45.0 (40.1–49.8) in HFA-PEFF 6. Similarly, HF readmission rates increased with increasing H2FPEF probability: <0.90 [31.8 (25.3–38.2) per 100 patient-years], 0.90–0.95 [41.5 (32.9–50.1)], and 0.96–1.00 [45.9 (41.2–50.6]. Median survival was 65 months (36–89 months) in HFA-PEFF score 2–4, 45 months (26–59 months) in HFA-PEFF score 5, and 28 months (22–42 months) in HFA-PEFF score 6 (P < 0.001), while the hazard ratio (95% confidence interval) for all-cause mortality was 1.16 (1.02–1.32) per 0.10 increase in H2FPEF probability. Conclusions: Among patients hospitalized with HFpEF, higher HFpEF probability according to diagnostic scores is associated with increased risk of subsequent HF readmissions and all-cause mortality.

Original languageEnglish (US)
JournalEuropean Journal of Heart Failure
DOIs
StateAccepted/In press - 2021

Keywords

  • Cause of death
  • Diastolic heart failure
  • Mortality
  • Patient readmission
  • Risk assessment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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