Abstract
Aims: To investigate the prognostic value of diagnostic scores for heart failure (HF) with preserved ejection fraction (HFpEF). Methods and results: Consecutive patients with HFpEF admitted for unequivocal decompensated HF treated with intravenous loop diuretics were evaluated (n = 443; mean age 78 ± 12 years; 60% women). The HFA-PEFF and H2FPEF scores were calculated for all patients with echocardiography data available within 1 year and the population was stratified according to HFA-PEFF scores 2–4 (n = 79), 5 (n = 93), or 6 (n = 271) and H2FPEF score probabilities <90% (n = 80), 90–95% (n = 61), and 96–100% (n = 293). HF readmission rates (95% confidence intervals) increased from 28.9 (22.7–35.0) per 100 patient-years in HFA-PEFF 2–4 to 46.0 (38.5–53.5) in HFA-PEFF 5 and 45.0 (40.1–49.8) in HFA-PEFF 6. Similarly, HF readmission rates increased with increasing H2FPEF probability: <0.90 [31.8 (25.3–38.2) per 100 patient-years], 0.90–0.95 [41.5 (32.9–50.1)], and 0.96–1.00 [45.9 (41.2–50.6]. Median survival was 65 months (36–89 months) in HFA-PEFF score 2–4, 45 months (26–59 months) in HFA-PEFF score 5, and 28 months (22–42 months) in HFA-PEFF score 6 (P < 0.001), while the hazard ratio (95% confidence interval) for all-cause mortality was 1.16 (1.02–1.32) per 0.10 increase in H2FPEF probability. Conclusions: Among patients hospitalized with HFpEF, higher HFpEF probability according to diagnostic scores is associated with increased risk of subsequent HF readmissions and all-cause mortality.
Original language | English (US) |
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Pages (from-to) | 954-963 |
Number of pages | 10 |
Journal | European Journal of Heart Failure |
Volume | 23 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2021 |
Keywords
- Cause of death
- Diastolic heart failure
- Mortality
- Patient readmission
- Risk assessment
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine