Diagnostic procedures for Parkinson's disease dementia: Recommendations from the Movement Disorder Society Task Force

Bruno Dubois, David Burn, Christopher Goetz, Dag Aarsland, Richard G. Brown, Gerald A. Broe, Dennis Dickson, Charles Duyckaerts, Jefferey Cummings, Serge Gauthier, Amos Korczyn, Andrew Lees, Richard Levy, Irene Litvan, Yoshikuni Mizuno, Ian G. McKeith, C. Warren Olanow, Werner Poewe, Cristina Sampaio, Eduardo TolosaMurat Emre

Research output: Contribution to journalReview articlepeer-review

677 Scopus citations

Abstract

A preceding article described the clinical features of Parkinson's disease dementia (PD-D) and proposed clinical diagnostic criteria for "probable" and "possible" PD-D. The main focus of this article is to operationalize the diagnosis of PD-D and to propose pratical guidelines based on a two level process depending upon the clinical scenario and the expertise of the evaluator involved in the assessment. Level I is aimed primarily at the clinician with no particular expertise in neuropsychological methods, but who requires a simple, pragmatic set of tests that are not excessively time-consuming. Level I can be used alone or in concert with Level II, which is more suitable when there is the need to specify the pattern and the severity on the dementia of PD-D for clinical monitoring, research studies or pharmacological trials. Level II tests can also be proposed when the diagnosis of PD-D remains uncertain or equivocal at the end of a Level I evaluation. Given the lack of evidence-based standards for some tests when applied in this clinical context, we have tried to make practical and unambiguous recommendations, based upon the available literature and the collective experience of the Task Force. We accept, however, that further validation of certain tests and modifications in the recommended cut off values will be required through future studies.

Original languageEnglish (US)
Pages (from-to)2314-2324
Number of pages11
JournalMovement Disorders
Volume22
Issue number16
DOIs
StatePublished - Dec 2007

Keywords

  • Diagnostic criteria
  • Executive functions
  • PD dementia
  • Parkinson's disease
  • Task force

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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