Diagnostic performance of breast magnetic resonance imaging in non-calcified equivocal breast findings: Results from a systematic review and meta-analysis

Barbara Bennani-Baiti, Nabila Bennani, Pascal A. Baltzer

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objectives: To evaluate the performance of MRI for diagnosis of breast cancer in non-calcified equivocal breast findings. Materials and Methods: We performed a systematic review and meta-analysis of peer-reviewed studies in PubMed from 01/01/1986 until 06/15/2015. Eligible were studies applying dynamic contrast-enhanced breast MRI as an adjunct to conventional imaging (mammography, ultrasound) to clarify equivocal findings without microcalcifications. Reference standard for MRI findings had to be established by histopathological sampling or imaging follow-up of at least 12 months. Number of true or false positives and negatives and other characteristics were extracted, and possible bias was determined using the QUADAS-2 applet. Statistical analyses included data pooling and heterogeneity testing. Results: Fourteen out of 514 studies comprising 2,316 lesions met our inclusion criteria. Pooled diagnostic parameters were: sensitivity (99%, 95%-CI: 93-100%), specificity (89%, 95%-CI: 85-92%), PPV (56%, 95%-CI: 42-70%) and NPV (100%, 95%-CI: 99-100%). These estimates displayed significant heterogeneity (P<0.001). Conclusions: Breast MRI demonstrates an excellent diagnostic performance in case of non-calcified equivocal breast findings detected in conventional imaging. However, considering the substantial heterogeneity with regard to prevalence of malignancy, problem solving criteria need to be better defined.

Original languageEnglish (US)
Article numbere0160346
JournalPloS one
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2016

Fingerprint

systematic review
Magnetic resonance
magnetic resonance imaging
meta-analysis
Magnetic resonance imaging
breasts
Meta-Analysis
Breast
Magnetic Resonance Imaging
Imaging techniques
Mammary Ultrasonography
image analysis
Calcinosis
Mammography
reference standards
peers
PubMed
breast neoplasms
ultrasonography
Ultrasonography

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Diagnostic performance of breast magnetic resonance imaging in non-calcified equivocal breast findings : Results from a systematic review and meta-analysis. / Bennani-Baiti, Barbara; Bennani, Nabila; Baltzer, Pascal A.

In: PloS one, Vol. 11, No. 8, e0160346, 01.08.2016.

Research output: Contribution to journalArticle

@article{c0bbaf71d9ef4b5eab82eee12696fb74,
title = "Diagnostic performance of breast magnetic resonance imaging in non-calcified equivocal breast findings: Results from a systematic review and meta-analysis",
abstract = "Objectives: To evaluate the performance of MRI for diagnosis of breast cancer in non-calcified equivocal breast findings. Materials and Methods: We performed a systematic review and meta-analysis of peer-reviewed studies in PubMed from 01/01/1986 until 06/15/2015. Eligible were studies applying dynamic contrast-enhanced breast MRI as an adjunct to conventional imaging (mammography, ultrasound) to clarify equivocal findings without microcalcifications. Reference standard for MRI findings had to be established by histopathological sampling or imaging follow-up of at least 12 months. Number of true or false positives and negatives and other characteristics were extracted, and possible bias was determined using the QUADAS-2 applet. Statistical analyses included data pooling and heterogeneity testing. Results: Fourteen out of 514 studies comprising 2,316 lesions met our inclusion criteria. Pooled diagnostic parameters were: sensitivity (99{\%}, 95{\%}-CI: 93-100{\%}), specificity (89{\%}, 95{\%}-CI: 85-92{\%}), PPV (56{\%}, 95{\%}-CI: 42-70{\%}) and NPV (100{\%}, 95{\%}-CI: 99-100{\%}). These estimates displayed significant heterogeneity (P<0.001). Conclusions: Breast MRI demonstrates an excellent diagnostic performance in case of non-calcified equivocal breast findings detected in conventional imaging. However, considering the substantial heterogeneity with regard to prevalence of malignancy, problem solving criteria need to be better defined.",
author = "Barbara Bennani-Baiti and Nabila Bennani and Baltzer, {Pascal A.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1371/journal.pone.0160346",
language = "English (US)",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

TY - JOUR

T1 - Diagnostic performance of breast magnetic resonance imaging in non-calcified equivocal breast findings

T2 - Results from a systematic review and meta-analysis

AU - Bennani-Baiti, Barbara

AU - Bennani, Nabila

AU - Baltzer, Pascal A.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objectives: To evaluate the performance of MRI for diagnosis of breast cancer in non-calcified equivocal breast findings. Materials and Methods: We performed a systematic review and meta-analysis of peer-reviewed studies in PubMed from 01/01/1986 until 06/15/2015. Eligible were studies applying dynamic contrast-enhanced breast MRI as an adjunct to conventional imaging (mammography, ultrasound) to clarify equivocal findings without microcalcifications. Reference standard for MRI findings had to be established by histopathological sampling or imaging follow-up of at least 12 months. Number of true or false positives and negatives and other characteristics were extracted, and possible bias was determined using the QUADAS-2 applet. Statistical analyses included data pooling and heterogeneity testing. Results: Fourteen out of 514 studies comprising 2,316 lesions met our inclusion criteria. Pooled diagnostic parameters were: sensitivity (99%, 95%-CI: 93-100%), specificity (89%, 95%-CI: 85-92%), PPV (56%, 95%-CI: 42-70%) and NPV (100%, 95%-CI: 99-100%). These estimates displayed significant heterogeneity (P<0.001). Conclusions: Breast MRI demonstrates an excellent diagnostic performance in case of non-calcified equivocal breast findings detected in conventional imaging. However, considering the substantial heterogeneity with regard to prevalence of malignancy, problem solving criteria need to be better defined.

AB - Objectives: To evaluate the performance of MRI for diagnosis of breast cancer in non-calcified equivocal breast findings. Materials and Methods: We performed a systematic review and meta-analysis of peer-reviewed studies in PubMed from 01/01/1986 until 06/15/2015. Eligible were studies applying dynamic contrast-enhanced breast MRI as an adjunct to conventional imaging (mammography, ultrasound) to clarify equivocal findings without microcalcifications. Reference standard for MRI findings had to be established by histopathological sampling or imaging follow-up of at least 12 months. Number of true or false positives and negatives and other characteristics were extracted, and possible bias was determined using the QUADAS-2 applet. Statistical analyses included data pooling and heterogeneity testing. Results: Fourteen out of 514 studies comprising 2,316 lesions met our inclusion criteria. Pooled diagnostic parameters were: sensitivity (99%, 95%-CI: 93-100%), specificity (89%, 95%-CI: 85-92%), PPV (56%, 95%-CI: 42-70%) and NPV (100%, 95%-CI: 99-100%). These estimates displayed significant heterogeneity (P<0.001). Conclusions: Breast MRI demonstrates an excellent diagnostic performance in case of non-calcified equivocal breast findings detected in conventional imaging. However, considering the substantial heterogeneity with regard to prevalence of malignancy, problem solving criteria need to be better defined.

UR - http://www.scopus.com/inward/record.url?scp=84982179084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982179084&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0160346

DO - 10.1371/journal.pone.0160346

M3 - Article

C2 - 27482715

AN - SCOPUS:84982179084

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e0160346

ER -