Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

Chris H. Polman, Stephen C. Reingold, Brenda Banwell, Michel Clanet, Jeffrey A. Cohen, Massimo Filippi, Kazuo Fujihara, Eva Havrdova, Michael Hutchinson, Ludwig Kappos, Fred D. Lublin, Xavier Montalban, Paul O'Connor, Magnhild Sandberg-Wollheim, Alan J. Thompson, Emmanuelle Waubant, Brian Weinshenker, Jerry S. Wolinsky

Research output: Contribution to journalArticlepeer-review

6057 Scopus citations


New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use.

Original languageEnglish (US)
Pages (from-to)292-302
Number of pages11
JournalAnnals of neurology
Issue number2
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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