Diagnostic criteria for monoclonal B-cell lymphocytosis

Gerald E. Marti, Andy C. Rawstron, Paolo Ghia, Peter Hillmen, Richard S. Houlston, Neil Elliot Kay, Thérèse A. Schleinitz, Neil Caporaso

Research output: Contribution to journalArticle

287 Citations (Scopus)

Abstract

Very low levels of circulating monoclonal B-cell subpopulations can now be detected in apparently healthy individuals using flow cytometry. We propose the term 'monoclonal B-cell lymphocytosis' (MBL) to describe this finding. The aim of this document is to provide a working definition of MBL for future clinical, epidemiological and laboratory studies. We propose that the detection of a monoclonal B-cell population by light chain restriction is sufficient to define this condition in individuals not meeting the diagnostic criteria for other B-lymphoproliferative disorders. The majority of individuals with MBL will have cells that are indistinguishable from chronic lymphocytic leukaemia (CLL). However, this blood cell clonal expansion of CD5+ or CD5- B-lymphocytes is age-dependent and immunophenotypic heterogeneity is common. Longitudinal studies are required to determine whether MBL is a precursor state to CLL or other B-lymphoproliferative disease in a situation analogous to a monoclonal gammopathy of undetermined significance and myeloma. Future studies of MBL should be directed towards determining its relationship to clinical disease, particularly in individuals from families with a genetic predisposition to developing CLL.

Original languageEnglish (US)
Pages (from-to)325-332
Number of pages8
JournalBritish Journal of Haematology
Volume130
Issue number3
DOIs
StatePublished - Aug 2005

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Lymphocytosis
B-Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Monoclonal Gammopathy of Undetermined Significance
Lymphoproliferative Disorders
Genetic Predisposition to Disease
Longitudinal Studies
Epidemiologic Studies
Blood Cells
Flow Cytometry
Light

Keywords

  • B cells
  • Early detection
  • Familial chronic lymphocytic leukaemia
  • Monoclonal B-cell lymphocytosis
  • Surrogate biomarker

ASJC Scopus subject areas

  • Hematology

Cite this

Marti, G. E., Rawstron, A. C., Ghia, P., Hillmen, P., Houlston, R. S., Kay, N. E., ... Caporaso, N. (2005). Diagnostic criteria for monoclonal B-cell lymphocytosis. British Journal of Haematology, 130(3), 325-332. https://doi.org/10.1111/j.1365-2141.2005.05550.x

Diagnostic criteria for monoclonal B-cell lymphocytosis. / Marti, Gerald E.; Rawstron, Andy C.; Ghia, Paolo; Hillmen, Peter; Houlston, Richard S.; Kay, Neil Elliot; Schleinitz, Thérèse A.; Caporaso, Neil.

In: British Journal of Haematology, Vol. 130, No. 3, 08.2005, p. 325-332.

Research output: Contribution to journalArticle

Marti, GE, Rawstron, AC, Ghia, P, Hillmen, P, Houlston, RS, Kay, NE, Schleinitz, TA & Caporaso, N 2005, 'Diagnostic criteria for monoclonal B-cell lymphocytosis', British Journal of Haematology, vol. 130, no. 3, pp. 325-332. https://doi.org/10.1111/j.1365-2141.2005.05550.x
Marti, Gerald E. ; Rawstron, Andy C. ; Ghia, Paolo ; Hillmen, Peter ; Houlston, Richard S. ; Kay, Neil Elliot ; Schleinitz, Thérèse A. ; Caporaso, Neil. / Diagnostic criteria for monoclonal B-cell lymphocytosis. In: British Journal of Haematology. 2005 ; Vol. 130, No. 3. pp. 325-332.
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