Diagnostic approach to well-differentiated hepatocellular carcinoma

Research output: Contribution to journalReview articlepeer-review


Well-differentiated hepatocellular mass-lesions in non-cirrhotic livers have a differential diagnosis of focal nodular hyperplasia, regenerative hepatic pseudotumors, hepatic adenoma, hepatocellular carcinoma, and fibrolamellar carcinoma. Despite significant advances in characterizing these pseudotumors and tumors, they remain a diagnostic challenge, especially on needle biopsy. This review focuses on a systematic diagnostic approach, one that allows confident diagnosis of these lesions.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalDiagnostic Histopathology
Issue number2
StatePublished - Feb 2022


  • Ki-67
  • focal nodular hyperplasia
  • glypican 3
  • hepatic adenoma
  • hepatocellular adenoma
  • hepatocellular carcinoma
  • regenerative hepatic pseudotumor
  • reticulin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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