Diagnostic approach to well-differentiated hepatocellular carcinoma

Michael S. Torbenson

doi:10.1016/j.mpdhp.2021.11.001

Diagnostic approach to well-differentiated hepatocellular carcinoma

Michael S. Torbenson

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

Abstract

Well-differentiated hepatocellular mass-lesions in non-cirrhotic livers have a differential diagnosis of focal nodular hyperplasia, regenerative hepatic pseudotumors, hepatic adenoma, hepatocellular carcinoma, and fibrolamellar carcinoma. Despite significant advances in characterizing these pseudotumors and tumors, they remain a diagnostic challenge, especially on needle biopsy. This review focuses on a systematic diagnostic approach, one that allows confident diagnosis of these lesions.

Original language	English (US)
Pages (from-to)	69-78
Number of pages	10
Journal	Diagnostic Histopathology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.mpdhp.2021.11.001
State	Published - Feb 2022

Keywords

Ki-67
focal nodular hyperplasia
glypican 3
hepatic adenoma
hepatocellular adenoma
hepatocellular carcinoma
regenerative hepatic pseudotumor
reticulin

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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10.1016/j.mpdhp.2021.11.001

Cite this

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title = "Diagnostic approach to well-differentiated hepatocellular carcinoma",

abstract = "Well-differentiated hepatocellular mass-lesions in non-cirrhotic livers have a differential diagnosis of focal nodular hyperplasia, regenerative hepatic pseudotumors, hepatic adenoma, hepatocellular carcinoma, and fibrolamellar carcinoma. Despite significant advances in characterizing these pseudotumors and tumors, they remain a diagnostic challenge, especially on needle biopsy. This review focuses on a systematic diagnostic approach, one that allows confident diagnosis of these lesions.",

keywords = "Ki-67, focal nodular hyperplasia, glypican 3, hepatic adenoma, hepatocellular adenoma, hepatocellular carcinoma, regenerative hepatic pseudotumor, reticulin",

author = "Torbenson, {Michael S.}",

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year = "2022",

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language = "English (US)",

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AU - Torbenson, Michael S.

PY - 2022/2

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N2 - Well-differentiated hepatocellular mass-lesions in non-cirrhotic livers have a differential diagnosis of focal nodular hyperplasia, regenerative hepatic pseudotumors, hepatic adenoma, hepatocellular carcinoma, and fibrolamellar carcinoma. Despite significant advances in characterizing these pseudotumors and tumors, they remain a diagnostic challenge, especially on needle biopsy. This review focuses on a systematic diagnostic approach, one that allows confident diagnosis of these lesions.

AB - Well-differentiated hepatocellular mass-lesions in non-cirrhotic livers have a differential diagnosis of focal nodular hyperplasia, regenerative hepatic pseudotumors, hepatic adenoma, hepatocellular carcinoma, and fibrolamellar carcinoma. Despite significant advances in characterizing these pseudotumors and tumors, they remain a diagnostic challenge, especially on needle biopsy. This review focuses on a systematic diagnostic approach, one that allows confident diagnosis of these lesions.

KW - Ki-67

KW - focal nodular hyperplasia

KW - glypican 3

KW - hepatic adenoma

KW - hepatocellular adenoma

KW - hepatocellular carcinoma

KW - regenerative hepatic pseudotumor

KW - reticulin

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DO - 10.1016/j.mpdhp.2021.11.001

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SN - 1756-2317

VL - 28

SP - 69

EP - 78

JO - Diagnostic Histopathology

JF - Diagnostic Histopathology

IS - 2

ER -

Diagnostic approach to well-differentiated hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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