Diagnostic Approach in Myeloproliferative Neoplasms

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter discusses contemporary diagnosis in myeloproliferative neoplasms (MPNs), which is according to the World Health Organization (WHO) system; this system is primarily based on morphology but also includes information from cytogenetic and molecular studies. The WHO recognizes five major categories of myeloid malignancies; one of these categories is MPNs, which comprise eight subcategories: chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), systemic mastocytosis (SM), chronic eosinophilic leukemia-not otherwise specified (CEL-NOS), chronic neutrophilic leukemia (CNL), and MPN unclassifiable (MPN-U). Bone marrow morphology is the cornerstone of specific diagnosis in MPNs.

Original languageEnglish (US)
Title of host publicationCancer Consult: Expertise for Clinical Practice
PublisherWiley Blackwell
Number of pages7
ISBN (Print)9781118589199, 9781118589212
StatePublished - Jun 20 2014


  • Bone marrow (BM) mastocytosis
  • Bone marrow morphology
  • Myeloid malignancies
  • Myeloproliferative neoplasms (MPNs)
  • Peripheral blood (PB) cytosis

ASJC Scopus subject areas

  • Medicine(all)


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