Diagnostic Approach in Myeloproliferative Neoplasms

This chapter discusses contemporary diagnosis in myeloproliferative neoplasms (MPNs), which is according to the World Health Organization (WHO) system; this system is primarily based on morphology but also includes information from cytogenetic and molecular studies. The WHO recognizes five major categories of myeloid malignancies; one of these categories is MPNs, which comprise eight subcategories: chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), systemic mastocytosis (SM), chronic eosinophilic leukemia-not otherwise specified (CEL-NOS), chronic neutrophilic leukemia (CNL), and MPN unclassifiable (MPN-U). Bone marrow morphology is the cornerstone of specific diagnosis in MPNs.