TY - JOUR
T1 - Diagnostic accuracy of the Berlin questionnaire in detecting sleep-disordered breathing in patients with a recent myocardial infarction
AU - Sert Kuniyoshi, Fatima H.
AU - Zellmer, Mark R.
AU - Calvin, Andrew D.
AU - Lopez-Jimenez, Francisco
AU - Albuquerque, Felipe N.
AU - Van Der Walt, Christelle
AU - Trombetta, Ivani C.
AU - Caples, Sean M.
AU - Shamsuzzaman, Abu S.
AU - Bukartyk, Jan
AU - Konecny, Tomas
AU - Gami, Apoor S.
AU - Kara, Tomas
AU - Somers, Virend K.
N1 - Funding Information:
Funding/Support: Dr Sert Kuniyoshi was supported by the American Heart Association [ Grant 09-20069G ]. Dr Calvin is supported by the Mayo Clinic Clinician-Investigator Training Program. Dr Somers is supported by National Institutes of Health (NIH) [ Grants HL65176 and 1 UL1 RR024150 ]. Dr Caples is supported by NIH [ Grant HL09953 ]. Dr Kara is supported by grants of IGA of Ministry of Health [ Grants NS 10098-4/2008 ] and by European Regional Development Fund, Project FNUSA-ICRC [ Grant CZ.1.05/1.1.00/02.0123 ]. These studies also were supported by a gift to Mayo Foundation by the Respironics Foundation for Sleep and Breathing.
Funding Information:
Role of sponsors: This publication was made possible by grant number 1 UL1 RR024150 from the National Center for Research Resources (NCRR) , a component of NIH and the NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NCRR or NIH. Information on NCRR is available at http://www.ncrr.nih.gov . Information on Reengineering the Clinical Research Enterprise can be obtained from http://nihroadmap.nih.gov . The sponsors had no role in the design of the study, the collection and analysis of the data, or in the preparation of the manuscript.
PY - 2011/11
Y1 - 2011/11
N2 - Background: The Berlin Questionnaire (BQ) has been used to identify patients at high risk for sleep-disordered breathing (SDB) in a variety of populations. However, there are no data regarding the validity of the BQ in detecting the presence of SDB in patients after myocardial infarction (MI). The aim of this study was to determine the performance of the BQ in patients after MI. Methods: We conducted a cross-sectional study of 99 patients who had an MI 1 to 3 months previously. The BQ was administered, scored using the published methods, and followed by completed overnight polysomnography as the "gold standard." SDB was defined as an apnea-hypopnea index of ≥ 5 events/h. The sensitivity, specificity, and positive and negative predictive values of the BQ were calculated. Results: Of the 99 patients, the BQ identified 64 (65%) as being at high-risk for having SDB. Overnight polysomnography showed that 73 (73%) had SDB. The BQ sensitivity and specificity was 0.68 and 0.34, respectively, with a positive predictive value of 0.68 and a negative predictive value of 0.50. Positive and negative likelihood ratios were 1.27 and 0.68, respectively, and the BQ overall diagnostic accuracy was 63%. Using different apnea-hypopnea index cutoff values did not meaningfully alter these results. Conclusion: The BQ performed with modest sensitivity, but the specificity was poor, suggesting that the BQ is not ideal in identifying SDB in patients with a recent MI.
AB - Background: The Berlin Questionnaire (BQ) has been used to identify patients at high risk for sleep-disordered breathing (SDB) in a variety of populations. However, there are no data regarding the validity of the BQ in detecting the presence of SDB in patients after myocardial infarction (MI). The aim of this study was to determine the performance of the BQ in patients after MI. Methods: We conducted a cross-sectional study of 99 patients who had an MI 1 to 3 months previously. The BQ was administered, scored using the published methods, and followed by completed overnight polysomnography as the "gold standard." SDB was defined as an apnea-hypopnea index of ≥ 5 events/h. The sensitivity, specificity, and positive and negative predictive values of the BQ were calculated. Results: Of the 99 patients, the BQ identified 64 (65%) as being at high-risk for having SDB. Overnight polysomnography showed that 73 (73%) had SDB. The BQ sensitivity and specificity was 0.68 and 0.34, respectively, with a positive predictive value of 0.68 and a negative predictive value of 0.50. Positive and negative likelihood ratios were 1.27 and 0.68, respectively, and the BQ overall diagnostic accuracy was 63%. Using different apnea-hypopnea index cutoff values did not meaningfully alter these results. Conclusion: The BQ performed with modest sensitivity, but the specificity was poor, suggesting that the BQ is not ideal in identifying SDB in patients with a recent MI.
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U2 - 10.1378/chest.10-2625
DO - 10.1378/chest.10-2625
M3 - Article
C2 - 21596794
AN - SCOPUS:81055141263
SN - 0012-3692
VL - 140
SP - 1192
EP - 1197
JO - Chest
JF - Chest
IS - 5
ER -