Diagnosis of pulmonary infection caused by Aspergillus: Usefulness of respiratory cultures

T. R. Treger, Daniel W Visscher, M. S. Bartlett, J. W. Smith

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Aspergillus infection is often difficult to diagnose, and the usefulness of methods of culture for diagnosis has been questioned. We reviewed all respiratory cultures that yielded any species of Aspergillus and all surgical and autopsy materials suspected or diagnostic of infection with Aspergillus over a two-year period. Of 89 patients with one or more positive cultures of nonbiopsy respiratory tract specimens, eight had histologically proven disease (three had aspergillomas and five, invasive aspergillosis). All cases of disease were due to Aspergillus fumigatus or Aspergillus flavus, and eight of nine patients with two or more positive cultures of A. fumigatus or A. flavus had proven disease, versus one of 81 who were uninfected (P < .001). Cultures from infected patients also had heavier growth and contained mixed Aspergillus species less often than did cultures from uninfected patients. We conclude that cultures of respiratory specimens are useful for diagnosis of pulmonary infection caused by Aspergillus.

Original languageEnglish (US)
Pages (from-to)572-576
Number of pages5
JournalJournal of Infectious Diseases
Volume152
Issue number3
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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