Diagnosis of a malignant adrenal mass: The role of urinary steroid metabolite profiling

Irina Bancos, Wiebke Arlt

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Purpose of review Adrenal masses are highly prevalent, found in 5% of the population. Differentiation of benign adrenocortical adenoma from adrenocortical carcinoma is currently hampered by the poor specificity and limited evidence base of imaging tests. This review summarizes the results of studies published to date on urine steroid metabolite profiling for distinguishing benign from malignant adrenal masses. Recent findings Three studies have described cohorts of at least 100 patients with adrenal tumors showing significant differences between urinary steroid metabolite excretions according to the nature of the underlying lesion, suggesting significant value of steroid metabolite profiling as a highly accurate diagnostic test. Summary Steroid profiling is emerging as a powerful novel diagnostic tool with a significant potential for improving the management for patients with adrenal tumors. Although the current studies use gas chromatography-mass spectrometry for proof of concept, widespread use of the method in routine clinical care will depend on transferring the approach to high-throughput tandem mass spectrometry platforms. The use of computational data analysis in conjunction with urine steroid metabolite profiling, that is, steroid metabolomics, adds accuracy and precision.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume24
Issue number3
DOIs
StatePublished - Jun 1 2017

Keywords

  • adrenal tumor
  • adrenocortical carcinoma
  • diagnostic test
  • mass spectrometry
  • steroid metabolomics
  • steroid profiling

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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