Diagnosis, management, and investigational therapies for food allergies

Mike Kulis, Benjamin Wright, Stacie M. Jones, A. Wesley Burks

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Food allergies have increased in prevalence over the past 20 years, now becoming an important public health concern. Although there are no therapies currently available for routine clinical care, recent reports have indicated that immunotherapies targeting the mucosal immune system may be effective. Oral immunotherapy is conducted by administering small, increasing amounts of food allergen; it has shown promise for desensitizing individuals with peanut, egg, or milk allergies. Sublingual immunotherapy also desensitizes allergic patients to foods - 2 major studies have examined the effects of sublingual immunotherapy in subjects with peanut allergies. We review the complex nature of IgE-mediated food allergies and the therapies being evaluated in clinical trials. We focus on the diagnosis and management of food allergies and investigational therapies.

Original languageEnglish (US)
Pages (from-to)1132-1142
Number of pages11
JournalGastroenterology
Volume148
Issue number6
DOIs
StatePublished - May 1 2015
Externally publishedYes

Keywords

  • Food Allergy
  • Oral Immunotherapy
  • Prevalence
  • Sublingual Immunotherapy

ASJC Scopus subject areas

  • Gastroenterology

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