Diagnosis and treatment strategies for mixed episodes in bipolar disorder

Susan L. McElroy, Mark A Frye, Joseph F. Goldberg, Roger S. McIntyre

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Dr. McIntyre reiterated that the management of acute states begins with clarifying the diagnosis, screening for comorbidity, and establishing therapeutic targets. Patients should be educated as to the likelihood and duration of recovery, and it should be understood that for many patients, combination treatment will be required. Multiple drugs are approved for the treatment of mixed states. The largest body of evidence supports the efficacy of atypical antipsychotics and divalproex. Lithium is suboptimally effective in mixed states, and antidepressants should be avoided due to their unproven efficacy and their association with treatment-emergent mania. Finally, clinicians should consider the use of an algorithm or treatment guideline in order to organize and optimize the care of patients with mixed-state bipolar disorder.

Original languageEnglish (US)
Pages (from-to)1971-1981
Number of pages11
JournalJournal of Clinical Psychiatry
Volume68
Issue number12
StatePublished - Dec 2007

Fingerprint

Bipolar Disorder
Therapeutics
Valproic Acid
Lithium
Antidepressive Agents
Antipsychotic Agents
Comorbidity
Patient Care
Guidelines
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

McElroy, S. L., Frye, M. A., Goldberg, J. F., & McIntyre, R. S. (2007). Diagnosis and treatment strategies for mixed episodes in bipolar disorder. Journal of Clinical Psychiatry, 68(12), 1971-1981.

Diagnosis and treatment strategies for mixed episodes in bipolar disorder. / McElroy, Susan L.; Frye, Mark A; Goldberg, Joseph F.; McIntyre, Roger S.

In: Journal of Clinical Psychiatry, Vol. 68, No. 12, 12.2007, p. 1971-1981.

Research output: Contribution to journalArticle

McElroy, SL, Frye, MA, Goldberg, JF & McIntyre, RS 2007, 'Diagnosis and treatment strategies for mixed episodes in bipolar disorder', Journal of Clinical Psychiatry, vol. 68, no. 12, pp. 1971-1981.
McElroy, Susan L. ; Frye, Mark A ; Goldberg, Joseph F. ; McIntyre, Roger S. / Diagnosis and treatment strategies for mixed episodes in bipolar disorder. In: Journal of Clinical Psychiatry. 2007 ; Vol. 68, No. 12. pp. 1971-1981.
@article{8559e45fb720449b87633cd59f0bab10,
title = "Diagnosis and treatment strategies for mixed episodes in bipolar disorder",
abstract = "Dr. McIntyre reiterated that the management of acute states begins with clarifying the diagnosis, screening for comorbidity, and establishing therapeutic targets. Patients should be educated as to the likelihood and duration of recovery, and it should be understood that for many patients, combination treatment will be required. Multiple drugs are approved for the treatment of mixed states. The largest body of evidence supports the efficacy of atypical antipsychotics and divalproex. Lithium is suboptimally effective in mixed states, and antidepressants should be avoided due to their unproven efficacy and their association with treatment-emergent mania. Finally, clinicians should consider the use of an algorithm or treatment guideline in order to organize and optimize the care of patients with mixed-state bipolar disorder.",
author = "McElroy, {Susan L.} and Frye, {Mark A} and Goldberg, {Joseph F.} and McIntyre, {Roger S.}",
year = "2007",
month = "12",
language = "English (US)",
volume = "68",
pages = "1971--1981",
journal = "Journal of Clinical Psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "12",

}

TY - JOUR

T1 - Diagnosis and treatment strategies for mixed episodes in bipolar disorder

AU - McElroy, Susan L.

AU - Frye, Mark A

AU - Goldberg, Joseph F.

AU - McIntyre, Roger S.

PY - 2007/12

Y1 - 2007/12

N2 - Dr. McIntyre reiterated that the management of acute states begins with clarifying the diagnosis, screening for comorbidity, and establishing therapeutic targets. Patients should be educated as to the likelihood and duration of recovery, and it should be understood that for many patients, combination treatment will be required. Multiple drugs are approved for the treatment of mixed states. The largest body of evidence supports the efficacy of atypical antipsychotics and divalproex. Lithium is suboptimally effective in mixed states, and antidepressants should be avoided due to their unproven efficacy and their association with treatment-emergent mania. Finally, clinicians should consider the use of an algorithm or treatment guideline in order to organize and optimize the care of patients with mixed-state bipolar disorder.

AB - Dr. McIntyre reiterated that the management of acute states begins with clarifying the diagnosis, screening for comorbidity, and establishing therapeutic targets. Patients should be educated as to the likelihood and duration of recovery, and it should be understood that for many patients, combination treatment will be required. Multiple drugs are approved for the treatment of mixed states. The largest body of evidence supports the efficacy of atypical antipsychotics and divalproex. Lithium is suboptimally effective in mixed states, and antidepressants should be avoided due to their unproven efficacy and their association with treatment-emergent mania. Finally, clinicians should consider the use of an algorithm or treatment guideline in order to organize and optimize the care of patients with mixed-state bipolar disorder.

UR - http://www.scopus.com/inward/record.url?scp=38049036753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049036753&partnerID=8YFLogxK

M3 - Article

C2 - 18162031

AN - SCOPUS:38049036753

VL - 68

SP - 1971

EP - 1981

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

SN - 0160-6689

IS - 12

ER -