Diagnosis and Treatment of Eosinophilic Esophagitis

Alex Straumann, David A Katzka

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Eosinophilic esophagitis (EoE) is a new disease. It is caused by a T-helper type 2 cell response to food antigens in contact with the esophageal mucosa. Although no single feature defines EoE, a constellation of compatible demographic, clinical, endoscopic, and histologic findings establish the diagnosis. Children present with symptoms and endoscopic patterns characteristic of inflammation, whereas adolescents and adults have manifestations of fibrosis and gross esophageal strictures. Clinical and endoscopic scoring systems have helped to standardize diagnosis. There is controversy in EoE research over the optimal endpoint for treatment. Although the most common endpoint is a reduced number of eosinophils in biopsies, changes in symptoms and endoscopic features are becoming important targets of therapy. We should improve our understanding of EoE progression and the need for maintenance therapy, and continue development of diagnostic tools that avoid endoscopy and biopsy analyses to more easily monitor disease activity.

Original languageEnglish (US)
Pages (from-to)346-359
Number of pages14
JournalGastroenterology
Volume154
Issue number2
DOIs
StatePublished - Jan 1 2018

Keywords

  • Eosinophilic Esophagitis
  • Esophagitis
  • Esophagus

ASJC Scopus subject areas

  • Gastroenterology

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