Diagnosis and treatment of chronic immune-mediated neuropathies

Norman Latov, Kenneth C. Gorson, Thomas H. Brannagan, Roy L. Freeman, Slobodan Apostolski, Alan R. Berger, Walter G. Bradley, Chiara Briani, Vera Bril, Neil A. Busis, Didier P. Cros, Marinos C. Dalakas, Peter D. Donofrio, P. James B. Dyck, John D. England, Morris A. Fisher, David N. Herrmann, Daniel L. Menkes, Zarife Sahenk, Howard W. SanderWilliam J. Triggs, Jean Michel Vallat

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The chronic autoimmune neuropathies are a diverse group of disorders, whose diagnosis and classification is based on the clinical presentations and results of ancillary tests. In chronic inflammatory demyelinating polyneuropathy, controlled therapeutic trials demonstrated efficacy for intravenous γ-globulins, corticosteroids, and plasmaphereis. In multifocal motor neuropathy, intravenous γ-globulins have been shown to be effective. In the other immune-mediated neuropathies, there are no reported controlled therapeutic trials, but efficacy has been reported for some treatments in non-controlled trials on case studies. Choice of therapy in individual cases is based on reported efficacy, as well as severity, progression, coexisting illness, predisposition to developing complications, and potential drug interactions.

Original languageEnglish (US)
Pages (from-to)141-157
Number of pages17
JournalJournal of clinical neuromuscular disease
Volume7
Issue number3
DOIs
StatePublished - Mar 2006

Keywords

  • Autoimmune neuropathy
  • Diagnosis
  • Inflammatory neuropathy
  • Peripheral neuropathy
  • Therapy
  • Vasculitic neuropathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Latov, N., Gorson, K. C., Brannagan, T. H., Freeman, R. L., Apostolski, S., Berger, A. R., Bradley, W. G., Briani, C., Bril, V., Busis, N. A., Cros, D. P., Dalakas, M. C., Donofrio, P. D., Dyck, P. J. B., England, J. D., Fisher, M. A., Herrmann, D. N., Menkes, D. L., Sahenk, Z., ... Vallat, J. M. (2006). Diagnosis and treatment of chronic immune-mediated neuropathies. Journal of clinical neuromuscular disease, 7(3), 141-157. https://doi.org/10.1097/01.cnd.0000205575.26451.e4