Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis)

Morie Gertz, Robert A. Kyle

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Amyloidosis is a group of disorders that have in common the deposition of protein fibrils composed of protofibrils that have a crystallographic β(beta)-pleated sheet structure. Disease results from these proteinaceous deposits in one or more organ systems [1]. The clinical presentation of amyloidosis varies greatly depending on the protein subunit of the amyloid fibril and the organs in which fibril deposition occurs [2]. Amyloidosis is classified on the basis of the structural subunit of the amyloid fibril protein.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Pages729-750
Number of pages22
ISBN (Electronic)9781461437642
ISBN (Print)1461437636, 9781461437635
DOIs
StatePublished - Nov 1 2013

Fingerprint

Immunoglobulin Light Chains
Amyloidosis
Amyloid
Amyloidogenic Proteins
Protein Subunits
Therapeutics
Proteins

Keywords

  • Amyloidosis
  • Bortezomib
  • Cardiac biomarkers
  • Congo red
  • Dexamethasone
  • Fat aspiration
  • Heart failure
  • Hepatomegaly
  • Immunoglobulin light chain
  • Lenalidomide
  • Melphalan
  • Monoclonal gammopathy
  • Multiple myeloma
  • Nephrotic syndrome
  • Peripheral neuropathy
  • Restrictive cardiomyopathy
  • Stem cell transplant
  • Thalidomide

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gertz, M., & Kyle, R. A. (2013). Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis). In Neoplastic Diseases of the Blood (pp. 729-750). Springer New York. https://doi.org/10.1007/978-1-4614-3764-2_37

Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis). / Gertz, Morie; Kyle, Robert A.

Neoplastic Diseases of the Blood. Springer New York, 2013. p. 729-750.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gertz, M & Kyle, RA 2013, Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis). in Neoplastic Diseases of the Blood. Springer New York, pp. 729-750. https://doi.org/10.1007/978-1-4614-3764-2_37
Gertz, Morie ; Kyle, Robert A. / Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis). Neoplastic Diseases of the Blood. Springer New York, 2013. pp. 729-750
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