Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis)

Morie A. Gertz; Robert A. Kyle

doi:10.1007/978-1-4614-3764-2_37

Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis)

Morie A. Gertz, Robert A. Kyle

Hematology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Amyloidosis is a group of disorders that have in common the deposition of protein fibrils composed of protofibrils that have a crystallographic β(beta)-pleated sheet structure. Disease results from these proteinaceous deposits in one or more organ systems [1]. The clinical presentation of amyloidosis varies greatly depending on the protein subunit of the amyloid fibril and the organs in which fibril deposition occurs [2]. Amyloidosis is classified on the basis of the structural subunit of the amyloid fibril protein.

Original language	English (US)
Title of host publication	Neoplastic Diseases of the Blood
Publisher	Springer New York
Pages	729-750
Number of pages	22
ISBN (Electronic)	9781461437642
ISBN (Print)	1461437636, 9781461437635
DOIs	https://doi.org/10.1007/978-1-4614-3764-2_37
State	Published - Nov 1 2013

Keywords

Amyloidosis
Bortezomib
Cardiac biomarkers
Congo red
Dexamethasone
Fat aspiration
Heart failure
Hepatomegaly
Immunoglobulin light chain
Lenalidomide
Melphalan
Monoclonal gammopathy
Multiple myeloma
Nephrotic syndrome
Peripheral neuropathy
Restrictive cardiomyopathy
Stem cell transplant
Thalidomide

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-3764-2_37

Cite this

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abstract = "Amyloidosis is a group of disorders that have in common the deposition of protein fibrils composed of protofibrils that have a crystallographic β(beta)-pleated sheet structure. Disease results from these proteinaceous deposits in one or more organ systems [1]. The clinical presentation of amyloidosis varies greatly depending on the protein subunit of the amyloid fibril and the organs in which fibril deposition occurs [2]. Amyloidosis is classified on the basis of the structural subunit of the amyloid fibril protein.",

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AU - Kyle, Robert A.

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AB - Amyloidosis is a group of disorders that have in common the deposition of protein fibrils composed of protofibrils that have a crystallographic β(beta)-pleated sheet structure. Disease results from these proteinaceous deposits in one or more organ systems [1]. The clinical presentation of amyloidosis varies greatly depending on the protein subunit of the amyloid fibril and the organs in which fibril deposition occurs [2]. Amyloidosis is classified on the basis of the structural subunit of the amyloid fibril protein.

KW - Amyloidosis

KW - Bortezomib

KW - Cardiac biomarkers

KW - Congo red

KW - Dexamethasone

KW - Fat aspiration

KW - Heart failure

KW - Hepatomegaly

KW - Immunoglobulin light chain

KW - Lenalidomide

KW - Melphalan

KW - Monoclonal gammopathy

KW - Multiple myeloma

KW - Nephrotic syndrome

KW - Peripheral neuropathy

KW - Restrictive cardiomyopathy

KW - Stem cell transplant

KW - Thalidomide

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SN - 1461437636

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BT - Neoplastic Diseases of the Blood

PB - Springer New York

ER -

Diagnosis and therapy of immunoglobulin light chain amyloidosis (AL amyloidosis)

Abstract

Keywords

ASJC Scopus subject areas

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