Diagnosis and prevalence of lanolin allergy

Rachel Y N Miest, James A. Yiannias, Yu Hui H Chang, Nidhi Singh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Current evaluation of suspected allergic contact dermatitis to lanolin includes patch testing to lanolin alcohol (30% in petrolatum). Using this method, the prevalence of lanolin allergy is low (1.8%-2.5%). Objective: The objective of this study was to determine whether patch testing to a single lanolin derivative results in underdiagnosis compared with patch testing to 12 lanolin derivatives. Methods: Patients were prospectively patch tested to (1) lanolin alcohol (30% in petrolatum) in our standard allergen series; (2) Amerchol L101 (50% in petrolatum) in our cosmetic series; and (3) 10 lanolin derivatives (using concentrations and vehicles recommended in the literature) in a supplemental series. Results: Of 286 patients, the overall prevalence of positive reactions to lanolin in at least 1 of the 3 patch test series was 6.29% (95% confidence interval [CI], 3.48%-9.11%) (n = 18). The prevalence rates of lanolin allergy using the standard, cosmetic, and supplemental series were 1.05% (95% CI, 0%-2.23%), 3.85% (95% CI, 1.62%-6.07%), and 3.85% (95% CI, 1.62%-6.07%), respectively. Amerchol L101 was associated with increased reaction rates compared with the standard (odds ratio, 3.81; P = 0.007) and supplemental (odds ratio, 8.85; P G 0.001) series, whereas reaction rates were similar for the standard and supplemental series (P = 0.78). Conclusions: Amerchol L101 and patients' own products should be added to a standard patch testing allergen series to adequately identify lanolin allergy.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalDermatitis
Volume24
Issue number3
DOIs
StatePublished - May 2013

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Lanolin
Hypersensitivity
Petrolatum
Confidence Intervals
Cosmetics
Allergens
Odds Ratio
Alcohols
Allergic Contact Dermatitis
Patch Tests

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy

Cite this

Miest, R. Y. N., Yiannias, J. A., Chang, Y. H. H., & Singh, N. (2013). Diagnosis and prevalence of lanolin allergy. Dermatitis, 24(3), 119-123. https://doi.org/10.1097/DER.0b013e3182937aa4

Diagnosis and prevalence of lanolin allergy. / Miest, Rachel Y N; Yiannias, James A.; Chang, Yu Hui H; Singh, Nidhi.

In: Dermatitis, Vol. 24, No. 3, 05.2013, p. 119-123.

Research output: Contribution to journalArticle

Miest, RYN, Yiannias, JA, Chang, YHH & Singh, N 2013, 'Diagnosis and prevalence of lanolin allergy', Dermatitis, vol. 24, no. 3, pp. 119-123. https://doi.org/10.1097/DER.0b013e3182937aa4
Miest RYN, Yiannias JA, Chang YHH, Singh N. Diagnosis and prevalence of lanolin allergy. Dermatitis. 2013 May;24(3):119-123. https://doi.org/10.1097/DER.0b013e3182937aa4
Miest, Rachel Y N ; Yiannias, James A. ; Chang, Yu Hui H ; Singh, Nidhi. / Diagnosis and prevalence of lanolin allergy. In: Dermatitis. 2013 ; Vol. 24, No. 3. pp. 119-123.
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abstract = "Background: Current evaluation of suspected allergic contact dermatitis to lanolin includes patch testing to lanolin alcohol (30{\%} in petrolatum). Using this method, the prevalence of lanolin allergy is low (1.8{\%}-2.5{\%}). Objective: The objective of this study was to determine whether patch testing to a single lanolin derivative results in underdiagnosis compared with patch testing to 12 lanolin derivatives. Methods: Patients were prospectively patch tested to (1) lanolin alcohol (30{\%} in petrolatum) in our standard allergen series; (2) Amerchol L101 (50{\%} in petrolatum) in our cosmetic series; and (3) 10 lanolin derivatives (using concentrations and vehicles recommended in the literature) in a supplemental series. Results: Of 286 patients, the overall prevalence of positive reactions to lanolin in at least 1 of the 3 patch test series was 6.29{\%} (95{\%} confidence interval [CI], 3.48{\%}-9.11{\%}) (n = 18). The prevalence rates of lanolin allergy using the standard, cosmetic, and supplemental series were 1.05{\%} (95{\%} CI, 0{\%}-2.23{\%}), 3.85{\%} (95{\%} CI, 1.62{\%}-6.07{\%}), and 3.85{\%} (95{\%} CI, 1.62{\%}-6.07{\%}), respectively. Amerchol L101 was associated with increased reaction rates compared with the standard (odds ratio, 3.81; P = 0.007) and supplemental (odds ratio, 8.85; P G 0.001) series, whereas reaction rates were similar for the standard and supplemental series (P = 0.78). Conclusions: Amerchol L101 and patients' own products should be added to a standard patch testing allergen series to adequately identify lanolin allergy.",
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